Khlusov I A, Karlov A V, Pozhen'ko N S, Sukhodolo I V, Khlusova M Yu
Center for Orthopaedics and Medical Materials Technology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Bull Exp Biol Med. 2006 Jan;141(1):99-103. doi: 10.1007/s10517-006-0104-5.
The capacity of mouse bone marrow cells to adhere to calcium phosphate surfaces and form tissue plates depending on the surface relief and solubility was studied in ectopic bone formation test. Calcium phosphate coating of titanium disks, made by the anodic spark (microarch) oxidation in 10% orthophosphoric acid with hydroxyl apatite particles, differed by the structure (thickness of coating, size of pores, and roughness) and solubility (level of in vitro oxidation of 1-week extracts of implants). Chemical (phasic and element) composition of the studied calcium phosphate coatings was virtually the same. The findings indicate that histogenesis is regulated by physicochemical characteristics of the implant surface. It seems that the osteogenic potential of calcium phosphate surfaces is largely determined by their relief, but not by pH of degradation products.
在异位骨形成试验中，研究了小鼠骨髓细胞根据表面起伏和溶解性附着于磷酸钙表面并形成组织板的能力。通过在含羟基磷灰石颗粒的10%正磷酸中进行阳极火花（微弧）氧化制成的钛盘磷酸钙涂层，在结构（涂层厚度、孔隙大小和粗糙度）和溶解性（植入物1周提取物的体外氧化水平）方面存在差异。所研究的磷酸钙涂层的化学（相和元素）组成基本相同。研究结果表明，组织发生受植入物表面物理化学特性的调节。似乎磷酸钙表面的成骨潜力很大程度上取决于其起伏，而非降解产物的pH值。
