一种来自抱茎苦荬菜的对K562细胞具有抑制作用的新型倍半萜内酯苷。

A new sesquiterpene lactone glucoside with inhibitory effect on K562 cells from Ixeris sonchifolia (Bge) Hance.

作者信息

He W-F, Xu B-B, Pan J-C, Lu J-C, Song S-J, Xu S-X

机构信息

School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, China.

出版信息

J Asian Nat Prod Res. 2006 Sep;8(6):481-4. doi: 10.1080/10286020500532140.

DOI:10.1080/10286020500532140

PMID:16931420

Abstract

A new minor sesquiterpene lactone glucoside, ixerin ZA (1), together with 16 known compounds, were isolated from the whole plants of Ixeris sonchifolia (Bge) Hance. The structure of 1 was elucidated as 1(10),3,11(13)-guaiatriene-12,6-olide-2-one-3-O-[6'-(p-metheoxyphenylacetyl)]-beta-glucopyranoside on the basis of spectroscopic and chemical evidence. Compound 1 exhibited an inhibitory effect on K562 cells.

摘要

从抱茎小苦荬（Ixeris sonchifolia (Bge) Hance）全草中分离得到一个新的倍半萜内酯苷类化合物——苦荬苷ZA（1）以及16个已知化合物。通过波谱和化学证据确定化合物1的结构为1(10),3,11(13)-愈创木三烯-12,6-内酯-2-酮-3-O-[6'-(对甲氧基苯乙酰基)]-β-D-吡喃葡萄糖苷。化合物1对K562细胞具有抑制作用。