苦荬菜叶子的细胞毒性成分。

Cytotoxic constituents of the leaves of Ixeris sonchifolia.

作者信息

Suh Jiyoung, Jo Youngmi, Kim Nam Deuk, Bae Song Ja, Jung Jee H, Im Kwang Sik

机构信息

College of Pharmacy, Pusan National University, Korea.

出版信息

Arch Pharm Res. 2002 Jun;25(3):289-92. doi: 10.1007/BF02976628.

DOI:10.1007/BF02976628

PMID:12135099

Abstract

The ethyl acetate extract of the leaves of Ixeris sonchifolia afforded two new and two known sesquiterpene lactone glucosides of the guaiane-type, together with a known alkenol glucoside. The known compounds were identified as ixerin Z (1), ixerin Z-6'-p-hydroxyphenylacetate (2), and (Z)-3-hexen-1-ol-beta-D-glucopyranoside (3), respectively. The structures of the new compounds were elucidated as 11,13a-dihydroixerin Z [4, 3-hydroxy-2-oxo-guaia-1(10), 3-dien-5alpha,6beta,7alpha, 11betaH-12,6-olide-3-O-beta-D-glucopyranoside], and 3,10beta-dihydroxy-2-oxo-guaia-3,11(13)-dien-1alpha,5alpha,6alpha,7aH-12,6-olide-10-O-beta-D-glucopyranoside (5), respectively. The cytotoxicity of these compounds against human hepatocellular carcinoma cell (HepG2) and human melanoma cell (SK-MEL-2) was evaluated.

摘要

抱茎苦荬菜叶片的乙酸乙酯提取物得到了两种新的和两种已知的愈创木烷型倍半萜内酯糖苷，以及一种已知的链烯醇糖苷。已知化合物分别被鉴定为苦荬菜苷Z（1）、苦荬菜苷Z-6'-对羟基苯乙酸酯（2）和（Z）-3-己烯-1-醇-β-D-葡萄糖苷（3）。新化合物的结构分别被阐明为11,13a-二氢苦荬菜苷Z [4, 3-羟基-2-氧代-愈创木-1(10), 3-二烯-5α,6β,7α, 11βH-12,6-内酯-3-O-β-D-葡萄糖苷] 和3,10β-二羟基-2-氧代-愈创木-3,11(13)-二烯-1α,5α,6α,7aH-12,6-内酯-10-O-β-D-葡萄糖苷（5）。评估了这些化合物对人肝癌细胞（HepG2）和人黑色素瘤细胞（SK-MEL-2）的细胞毒性。