Ezzat Shereen, Asa Sylvia L
The Freeman Centre for Endocrine Oncology, Mount Sinai Hospital, Toronto, Ontario, Canada.
Nat Clin Pract Endocrinol Metab. 2006 Apr;2(4):220-30. doi: 10.1038/ncpendmet0159.
Pituitary tumors exhibit a spectrum of biology, with variable growth and hormonal behaviors. They therefore provide an opportunity to examine pathogenetic mechanisms that underlie the neoplastic process. These include alterations in hormone regulation, growth-factor stimulation, cell-cycle control and cell-stromal interactions that result from genetic mutations or epigenetic disruption of gene expression. Mouse models have validated the roles of these alterations, which can be targets for the development of therapies that can manage these lesions. These therapies are increasingly recognized as critical for quality of life.
垂体肿瘤表现出一系列生物学特性，其生长和激素行为各不相同。因此，它们为研究肿瘤形成过程背后的致病机制提供了一个机会。这些机制包括激素调节、生长因子刺激、细胞周期控制以及细胞与基质相互作用的改变，这些改变是由基因突变或基因表达的表观遗传破坏引起的。小鼠模型已经证实了这些改变的作用，它们可以成为开发治疗这些病变的疗法的靶点。这些疗法对于生活质量的重要性日益得到认可。
