Sarasa J L, Ramon y Cajal Agüeras S, Burzaco J
Department of Pathology, Fundacion Jimenez Diaz, Madrid, Spain.
Ultrastruct Pathol. 1990 Mar-Apr;14(2):151-9. doi: 10.1080/01913129009025127.
The report describes an oligodendroglioma that was examined in four biopsies and contained a large number of intracytoplasmic crystals. The crystals appeared in neoplastic cells with eosinophilic cytoplasms and eccentric nuclei. They were positive to periodic acid-Schiff stain and resistant to diastase. A lysosomal genesis of the crystals is proposed on the basis of a transition observed between lysosomal bodies with lipid droplets and those with crystalloid electron-dense structures. The morphologic and histochemical features of these crystals are compared to those in other tumors, lesions, and nonneoplastic cells.
该报告描述了一例少突胶质细胞瘤，其在四次活检中均有检查，且含有大量胞质内晶体。这些晶体出现在具有嗜酸性细胞质和偏心核的肿瘤细胞中。它们对过碘酸希夫染色呈阳性，对淀粉酶具有抗性。基于在含有脂滴的溶酶体与含有晶体样电子致密结构的溶酶体之间观察到的转变，提出了晶体的溶酶体起源。将这些晶体的形态学和组织化学特征与其他肿瘤、病变及非肿瘤细胞中的特征进行了比较。
