Huang Jianping, Coman David, McTaggart Steven J, Burke John R
Queensland Child and Adolescent Renal Service, Royal Children's Hospital and Mater Children's Hospitals, Brisbane, Queensland, Australia.
Pediatr Nephrol. 2006 Nov;21(11):1676-80. doi: 10.1007/s00467-006-0217-0. Epub 2006 Aug 24.
Idiopathic infantile hypercalcaemia (IIH) is a rare disorder of unknown etiology that presents with hypercalcaemia in a child's first year of life. There is only a limited number of published reports of the natural history of this condition, and the long-term prognosis is largely unknown. The presentation, treatment and long-term follow-up of 11 children with IIH treated at our institution since 1993 are described. Hypercalcaemia resolved in the majority of children by the time they were 3 years of age, but nephrocalcinosis and persistent hypercalciuria were common, and, in some cases, urinary calcium excretion increased after initially becoming normal. This study suggests that clinical and biochemical abnormalities may persist for longer than previously reported and implies the need for ongoing surveillance of patients with IIH.
特发性婴儿高钙血症（IIH）是一种病因不明的罕见疾病，在儿童出生后的第一年出现高钙血症。关于这种疾病自然史的已发表报告数量有限，其长期预后在很大程度上尚不清楚。本文描述了自1993年以来在我们机构接受治疗的11例IIH患儿的临床表现、治疗及长期随访情况。大多数患儿在3岁时高钙血症得以缓解，但肾钙质沉着症和持续性高钙尿症很常见，而且在某些情况下，尿钙排泄在最初恢复正常后又有所增加。这项研究表明，临床和生化异常可能比之前报道的持续时间更长，这意味着需要对IIH患者进行持续监测。
