Rischewski Johannes R, Imbach Paul, Paulussen Michael, Kühne Thomas
Department of Pediatric Oncology/Hematology, University Children's Hospital Basel (UKBB), Basel, Switzerland.
Pediatr Blood Cancer. 2006 Oct 15;47(5 Suppl):678-80. doi: 10.1002/pbc.21005.
Idiopathic thrombocytopenic purpura (ITP) is a diagnosis of exclusion. It is unknown, whether familial ITP exists. Familial cases would make a genetic susceptibility for ITP possible. Data of the Pediatric and Adult Registry on Chronic ITP (PARC-ITP) were reviewed and subsequently ITP patients from Basel investigated for cases with a positive family history. In 10 of 445 pediatric patients and in 2 of 21 patients from Basel the family history was positive. A surprisingly high number of ITP patients with a positive family history were identified, indicating the likely existence of a genetic susceptibility for ITP.
特发性血小板减少性紫癜（ITP）是一种排除性诊断。目前尚不清楚是否存在家族性ITP。家族性病例可能提示ITP存在遗传易感性。我们回顾了慢性ITP的儿科和成人登记处（PARC-ITP）的数据，随后对来自巴塞尔的ITP患者进行了调查，以寻找家族史阳性的病例。在445例儿科患者中有10例以及来自巴塞尔的21例患者中有2例家族史呈阳性。我们发现家族史阳性的ITP患者数量惊人地高，这表明ITP可能存在遗传易感性。
