Sánchez Fayos J, Olavarría E, Román A, Cabello A, Soto C, Paniagua C
Servicio de Hematología y Hemoterapia, Fundación Jiménez Díaz Facultad de Medicina de la Universidad Autónoma de Madrid.
Sangre (Barc). 1994 Jun;39(3):215-7.
Five cases of idiopathic thrombocytopenic purpura (ITP) appearing on five members of two generations of a family, with autosomal dominant pattern, are presented. The clinico-biologic behaviour of 2 patients (studied and treated by the authors) plus the available data from the 3 others (diagnosed and treated at other hospitals) allowed us to discard any possibility of hereditary non-immunologic thrombocytopenia. The predisposition of ITP patients and their relatives to present clinico-biological features of autoimmune diseases is commented as a possible explanation for the rare forms of familial ITP.
本文报告了一个家族两代五名成员患特发性血小板减少性紫癜（ITP）的病例，呈常染色体显性遗传模式。通过对2例患者（作者进行研究和治疗）的临床生物学行为以及其他3例患者（在其他医院诊断和治疗）的现有数据进行分析，我们排除了遗传性非免疫性血小板减少症的可能性。文中还讨论了ITP患者及其亲属易出现自身免疫性疾病临床生物学特征的情况，以此作为家族性ITP罕见形式的一种可能解释。
