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1,25-二羟维生素D3与增加细胞内3',5'-环磷酸腺苷的药物协同抑制人淋巴细胞的促有丝分裂刺激。

1,25-dihydroxyvitamin D3 and agents that increase intracellular adenosine 3',5'-monophosphate synergistically inhibit the mitogenic stimulation of human lymphocytes.

作者信息

Ravid A, Koren R, Narinsky R, Rotem C, Novogrodsky A, Liberman A

机构信息

Rogoff Medical Research Institute, Petah Tikva, Israel.

出版信息

J Clin Endocrinol Metab. 1990 Jun;70(6):1687-92. doi: 10.1210/jcem-70-6-1687.

DOI:10.1210/jcem-70-6-1687
PMID:1693374
Abstract

1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], like the immune response modulators prostaglandin E2 (PGE2) and histamine, inhibits mitogen-induced proliferation of human peripheral blood mononuclear cells. 1,25-(OH)2D3 acts synergistically with PGE2 and histamine to inhibit lymphocyte mitogenesis. This is apparent at a wide concentration range of 1,25-(OH)2D3 (3 X 10(-11)-10(-8) mol/L). Cholera toxin, forskolin, and isobutylmethylxanthine, which like PGE2 and histamine increase intracellular concentrations of cAMP, also act synergistically with 1,25-(OH)2D3 in this system. Culture of mitogen-stimulated adherent cell-depleted mononuclear cells with PGE2 increases the number of high affinity binding sites for 1,25-(OH)2D3. This finding may account for the synergistic interaction between the two agents.

摘要

1,25 - 二羟基维生素D3 [1,25-(OH)2D3] 与免疫反应调节剂前列腺素E2（PGE2）和组胺一样，可抑制有丝分裂原诱导的人外周血单个核细胞增殖。1,25-(OH)2D3 与PGE2 和组胺协同作用，抑制淋巴细胞有丝分裂。这在1,25-(OH)2D3 的广泛浓度范围（3×10(-11)-10(-8) mol/L）内都很明显。霍乱毒素、福斯可林和异丁基甲基黄嘌呤，它们与PGE2 和组胺一样会增加细胞内cAMP 浓度，在该系统中也与1,25-(OH)2D3 协同作用。用PGE2 培养有丝分裂原刺激的去除贴壁细胞的单个核细胞，会增加1,25-(OH)2D3 的高亲和力结合位点数量。这一发现可能解释了这两种物质之间的协同相互作用。

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