Sloven D G, Jirapinyo P, Lebenthal E
International Institute for Infant Nutrition and Gastrointestinal Disease, Children's Hospital of Buffalo, New York.
J Pediatr. 1990 Jun;116(6):876-81. doi: 10.1016/s0022-3476(05)80643-2.
Because rice remains the most available carbohydrate in developing countries, where chronic diarrhea is most prevalent, we compared the in vitro hydrolysis and clinical tolerance of rice glucose polymer with those of corn glucose polymer. Rice glucose polymer hydrolysis to D-glucose and short-chain polymers (polymers with two to four glucose units and those with five or more units) was similar to that for corn glucose polymers during incubation with saliva or duodenal aspirates. However, rice glucose polymers yielded more short-chain products than corn glucose polymers during incubation with pooled mucosal homogenates (p less than 0.01). In vivo tolerance testing of 16 infants with chronic diarrhea confirmed that rice glucose polymers were well tolerated and, compared with corn glucose polymers, achieved a higher maximal increase of serum glucose concentration (36.6 +/- 7.3 vs 27.6 +/- 10.3 mg/dl; p less than 0.02), a shorter time to peak serum glucose concentration (34.0 +/- 10.2 vs 52.5 +/- 25.7 minutes; p less than 0.02), and a greater area under the serum glucose response curve at 30 minutes (538 +/- 131 vs 1035 +/- 501 cm; p less than 0.02). We conclude that rice glucose polymers are rapidly hydrolyzed in vitro and in vivo and are more rapidly absorbed than are corn glucose polymers in children with chronic diarrhea.
由于在慢性腹泻最为普遍的发展中国家，大米仍是最易获取的碳水化合物，我们比较了大米葡萄糖聚合物与玉米葡萄糖聚合物的体外水解情况及临床耐受性。在与唾液或十二指肠吸出物一起孵育时，大米葡萄糖聚合物水解为D - 葡萄糖和短链聚合物（含两至四个葡萄糖单位的聚合物以及含五个或更多单位的聚合物）的情况与玉米葡萄糖聚合物相似。然而，在与合并的黏膜匀浆一起孵育时，大米葡萄糖聚合物产生的短链产物比玉米葡萄糖聚合物更多（p小于0.01）。对16名慢性腹泻婴儿进行的体内耐受性测试证实，大米葡萄糖聚合物耐受性良好，与玉米葡萄糖聚合物相比，血清葡萄糖浓度的最大增加值更高（36.6±7.3对27.6±10.3mg/dl；p小于0.02），达到血清葡萄糖浓度峰值的时间更短（34.0±10.2对52.5±25.7分钟；p小于0.02），并且在30分钟时血清葡萄糖反应曲线下的面积更大（538±131对1035±501cm；p小于0.02）。我们得出结论，在体外和体内，大米葡萄糖聚合物都能快速水解，并且在慢性腹泻儿童中比玉米葡萄糖聚合物吸收得更快。
