Zheng B Y, Lu R B, Maiese R L, Maiese S, Lebenthal E
Department of Pediatrics, International Institute for Infant Nutrition and Gastrointestinal Disease, Hahnemann University, Philadelphia, Pennsylvania.
Gastroenterology. 1993 Jan;104(1):81-5. doi: 10.1016/0016-5085(93)90838-4.
This study aims to determine the effect of replacing glucose in oral rehydration solution (ORS) with starch hydrolysates from rice on absorption in the small intestine and levels of glucose in portal venous blood and on disaccharidase levels and morphometric measurements in intestines of rats.
ORS containing standard composition of salts and 2% glucose (WHO ORS) or 2%, 5%, or 10% starch hydrolysates were infused into duodena of 60 Sprague-Dawley rats (250-350 g). Portal venous blood glucose levels were determined at 0, 30, 60, 90, and 120 minutes.
Significantly larger areas under the curve of glucose absorption (AUCs) were produced by ORS containing 10% unfractionated starch hydrolysates (123.2 +/- 3.8), 2%, 5%, and 10% starch hydrolysates with long-chain ( > 9 molecules) glucose polymers (109.5 +/- 10.6, 109.3 +/- 7.4, and 115.3 +/- 7.1, respectively), and 5% and 10% starch hydrolysates with short-chain (2-9 molecules) glucose polymers (124.4 +/- 6.1 and 128.1 +/- 6.8). ORS with 2% and 5% unfractionated starch hydrolysates and 2% short-chain glucose polymers produced AUCs comparable with those of WHO ORS (96.48 +/- 5.7). Disaccharidase levels and morphometric measurements were not significantly different.
Starch hydrolysates from rice containing glucose polymers can be used in ORS in higher concentrations than glucose to provide higher caloric density without increased osmolality.
本研究旨在确定用大米淀粉水解产物替代口服补液盐（ORS）中的葡萄糖对大鼠小肠吸收、门静脉血葡萄糖水平、双糖酶水平及肠道形态学测量的影响。
将含有标准盐成分和2%葡萄糖（世界卫生组织ORS）或2%、5%或10%淀粉水解产物的ORS注入60只体重250 - 350克的斯普拉格-道利大鼠的十二指肠。在0、30、60、90和120分钟时测定门静脉血葡萄糖水平。
含有10%未分级淀粉水解产物（123.2±3.8）、含长链（>9个分子）葡萄糖聚合物的2%、5%和10%淀粉水解产物（分别为109.5±10.6、109.3±7.4和115.3±7.1）以及含短链（2 - 9个分子）葡萄糖聚合物的5%和10%淀粉水解产物（124.4±6.1和128.1±6.8）的ORS产生的葡萄糖吸收曲线下面积（AUC）显著更大。含有2%和5%未分级淀粉水解产物以及2%短链葡萄糖聚合物的ORS产生的AUC与世界卫生组织ORS相当（96.48±5.7）。双糖酶水平和形态学测量无显著差异。
含葡萄糖聚合物的大米淀粉水解产物可用于ORS中，其浓度高于葡萄糖，能提供更高的热量密度且不增加渗透压。
