Adem Patricia V, Montgomery Christopher P, Husain Aliya N, Koogler Tracy K, Arangelovich Valerie, Humilier Michel, Boyle-Vavra Susan, Daum Robert S
Department of Pathology, University of Chicago, USA.
N Engl J Med. 2005 Sep 22;353(12):1245-51. doi: 10.1056/NEJMoa044194.
Staphylococcus aureus has increasingly been recognized as a cause of severe invasive illness. We describe three children who died at our institution after rapidly progressive clinical deterioration from this infection, with necrotizing pneumonia and multiple-organ-system involvement. The identification of bilateral adrenal hemorrhage at autopsy was characteristic of the Waterhouse-Friderichsen syndrome, a constellation of findings usually associated with fulminant meningococcemia. The close genetic relationship among the three responsible isolates of S. aureus, one susceptible to methicillin and two resistant to methicillin, underscores the close relationship between virulent methicillin-susceptible S. aureus and methicillin-resistant S. aureus isolates now circulating in the community.
金黄色葡萄球菌越来越被认为是严重侵袭性疾病的病因。我们描述了三名儿童，他们在我院因这种感染导致临床迅速恶化后死亡，伴有坏死性肺炎和多器官系统受累。尸检时发现双侧肾上腺出血是华-佛综合征的特征，这是一组通常与暴发性脑膜炎球菌血症相关的表现。三种致病的金黄色葡萄球菌分离株之间密切的遗传关系，其中一株对甲氧西林敏感，两株对甲氧西林耐药，突显了社区中目前流行的毒力强的甲氧西林敏感金黄色葡萄球菌与甲氧西林耐药金黄色葡萄球菌分离株之间的密切关系。
