Dreyfus Gilles D, Souza Neto Olivio, Aubert Stéphane
Department of Cardiothoracic Surgery, Royal Brompton and Harefield NHS Trust London, Harefield Hospital, Harefield, Middlesex, United Kingdom.
J Thorac Cardiovasc Surg. 2006 Sep;132(3):578-84. doi: 10.1016/j.jtcvs.2006.06.003.
Anterior leaflet prolapse is still a challenge. Various techniques have been described, but very little is known of the long-term outcome. We describe the long-term results of papillary muscle repositioning, with up to 15 years' follow-up.
From 1989 through 2005, 120 patients with anterior leaflet prolapse (97 bileaflet and 23 isolated anterior leaflet) were treated with papillary muscle repositioning when chordae were elongated. All patients had severe mitral regurgitation. The mean left ventricular end-systolic diameter on echocardiography was 39.4 +/- 5.2 mm. The predominant cause was degenerative: dystrophic disease in 62 and Barlow's disease in 43. Papillary muscle repositioning was carried out on the posterior papillary muscle in 92.5% and on the anterior papillary muscle in 31.7%. A ring annuloplasty was performed in 117 cases. Fifty-seven (47.5%) patients had a tricuspid annuloplasty.
There were no in-hospital deaths or patients lost to follow-up. Mean follow-up was 6.3 +/- 0.4 years (maximum, 15.6 years). Cumulative actuarial survival at 5, 10, and 15 years was 97.2%, 94.1%, and 81.4%, respectively. Two (1.7%) patients required reoperation at 1 and 5 years after repair. No significant risk factor was identified for late mortality or reoperation. At the latest assessment, 88 (73.3%) patients were asymptomatic. Echocardiography showed no or trivial mitral regurgitation in 89 (74.2%) patients, mild mitral regurgitation in 8 patients, and moderate mitral regurgitation in 9 patients.
Anterior leaflet prolapse caused by elongated chordae can always be addressed with papillary muscle repositioning. Results indicate that it is a safe and durable technique, providing good long-term results in the management of degenerative pathology of the anterior leaflet.
二尖瓣前叶脱垂仍是一个具有挑战性的问题。虽然已经描述了多种技术,但对于其长期结果却知之甚少。我们描述了乳头肌重新定位的长期结果,随访时间长达15年。
从1989年至2005年,120例二尖瓣前叶脱垂患者(97例为双叶脱垂,23例为孤立性前叶脱垂)在腱索延长时接受了乳头肌重新定位治疗。所有患者均有严重二尖瓣反流。超声心动图显示左心室收缩末期平均直径为39.4±5.2mm。主要病因是退行性病变:62例为营养不良性疾病,43例为巴洛病。92.5%的患者对后乳头肌进行了重新定位,31.7%的患者对前乳头肌进行了重新定位。117例患者进行了瓣环成形术。57例(47.5%)患者进行了三尖瓣瓣环成形术。
无院内死亡病例,也无失访患者。平均随访时间为6.3±0.4年(最长15.6年)。5年、10年和15年的累积精算生存率分别为97.2%、94.1%和81.4%。2例(1.7%)患者在修复后1年和5年需要再次手术。未发现晚期死亡或再次手术的显著危险因素。在最近一次评估时,88例(73.3%)患者无症状。超声心动图显示89例(74.2%)患者无或仅有微量二尖瓣反流,8例患者有轻度二尖瓣反流,9例患者有中度二尖瓣反流。
腱索延长导致的二尖瓣前叶脱垂总是可以通过乳头肌重新定位来解决。结果表明,这是一种安全且持久的技术,在前叶退行性病变的管理中能提供良好的长期效果。