Newcom S R, Muth L H, Parker E T
Department of Medicine, Emory University School of Medicine, Atlanta, GA.
Blood. 1990 Jun 15;75(12):2434-7.
High molecular weight transforming growth factor-beta (TGF beta) is a physiologically active TGF secreted by nodular sclerosing Reed-Sternberg cells. Five monoclonal murine antibodies were prepared that distinguished Hodgkin's TGF beta from platelet-derived TGF beta using an enzyme-linked immunosorbent assay, neutralization of biologic activity, and Western blotting. These monoclonal antibodies directed at unique antigenic determinants (epitopes) of Hodgkin's TGF beta will allow further characterization of the role of Hodgkin's TGF beta in Hodgkin's disease and related entities.
高分子量转化生长因子-β（TGF-β）是结节硬化型里德-斯腾伯格细胞分泌的一种具有生理活性的TGF。制备了五种单克隆鼠抗体，利用酶联免疫吸附测定、生物活性中和及蛋白质免疫印迹法区分霍奇金淋巴瘤的TGF-β与血小板衍生的TGF-β。这些针对霍奇金淋巴瘤TGF-β独特抗原决定簇（表位）的单克隆抗体将有助于进一步阐明霍奇金淋巴瘤TGF-β在霍奇金病及相关疾病中的作用。
