Baker K Adam, Moore Simon W, Jarjour Andrew A, Kennedy Timothy E
Centre for Neuronal Survival, Montréal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, H3A 2B4, Canada.
Curr Opin Neurobiol. 2006 Oct;16(5):529-34. doi: 10.1016/j.conb.2006.08.002. Epub 2006 Aug 28.
Netrins are a small family of secreted proteins that are best known for their role as secreted long-range chemotropic guidance cues. Extracellular gradients of netrin protein, established by diffusion, are thought to direct cell and axon migration during neural development. In addition to this long-range role, recent findings provide increasing support for short-range functions, in which secreted netrin protein remains closely associated with its cellular source. Emerging evidence for short-range actions of netrins suggests that they contribute to tissue morphogenesis by regulating cell-cell and cell-matrix adhesion.
Netrins是一个分泌蛋白的小家族，它们最为人所知的是作为分泌型远程化学趋向性引导信号发挥作用。由扩散建立的Netrin蛋白细胞外梯度被认为在神经发育过程中指导细胞和轴突迁移。除了这种远程作用外，最近的研究结果越来越支持其短程功能，即分泌的Netrin蛋白与其细胞来源保持密切关联。Netrins短程作用的新证据表明，它们通过调节细胞-细胞和细胞-基质粘附来促进组织形态发生。
