Jansen Nathalie C, Kingma Annette, Schuitema Arnout, Bouma Anke, Huisman Jaap, Veerman Anjo J, Kamps Willem A
Department of Paediatric Haematology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, P.O. Box 30 001, Groningen 9700 RB, The Netherlands.
Eur J Cancer. 2006 Nov;42(16):2765-72. doi: 10.1016/j.ejca.2006.06.014. Epub 2006 Aug 28.
Intellectual functioning (verbal, performance and full-scale IQ) in 43 children treated for acute lymphoblastic leukaemia (ALL) with chemotherapy-only was evaluated in a nationwide, prospective, sibling-controlled study. Intellectual assessment was performed at diagnosis and repeated shortly after cessation of 2 years treatment, including intrathecal and systemic chemotherapy. Using hierarchical regression analysis, patients' and siblings' (n=27) scores were longitudinally analysed and compared to assess possible changes and differences over time. At both assessments, before and after treatment, the patients showed average scores on intelligence tests compared to population norms. Longitudinal analysis and cross-sectional comparisons revealed no significant differences between patients and controls. Young patients showed a small relative decline, albeit not significant, on performance-IQ compared to healthy siblings. Despite intensive and potentially neurotoxic treatment, no evident negative effects on intelligence were found. However, it cannot be precluded that younger patients are at risk for a small decline in PIQ.
在一项全国性的前瞻性同胞对照研究中，对43名仅接受化疗治疗急性淋巴细胞白血病（ALL）的儿童的智力功能（语言、操作和全量表智商）进行了评估。在诊断时进行智力评估，并在2年治疗结束后不久（包括鞘内和全身化疗）再次进行评估。使用分层回归分析，对患者和同胞（n = 27）的得分进行纵向分析和比较，以评估随时间可能出现的变化和差异。在治疗前后的两次评估中, 与总体常模相比，患者在智力测试中的得分处于平均水平。纵向分析和横断面比较显示，患者与对照组之间没有显著差异。与健康同胞相比，年轻患者在操作智商上有较小的相对下降，尽管不显著。尽管进行了强化且可能具有神经毒性的治疗，但未发现对智力有明显的负面影响。然而，不能排除年轻患者有操作智商小幅下降的风险。
