Protas Piotr T, Muszynska-Roslan Katarzyna, Holownia Adam, Grabowska Aleksandra, Wielgat Przemyslaw, Krawczuk-Rybak Maryna, Braszko Jan J
Department of Clinical Pharmacology, Medical University of Bialystok, Bialystok, Waszyngtona, Poland.
Pediatr Blood Cancer. 2009 Jul;53(1):105-8. doi: 10.1002/pbc.22029.
The aim of the study was to assess whether cerebrospinal fluid tau protein is associated with cognitive changes in children with acute lymphoblastic leukemia (ALL). Examination of 38 ALL patients revealed a statistically significant increase in tau protein on treatment day 59 and at two points during consolidation phase. Cognitive functioning was examined in 19 patients at an average of 3.7 years after diagnosis. The level of tau at the initiation of maintenance therapy was negatively correlated with verbal abilities measured on an intellectual scale. The study suggests that standard ALL treatment may cause a decline in cognitive functioning.
该研究的目的是评估脑脊液tau蛋白是否与急性淋巴细胞白血病（ALL）患儿的认知变化有关。对38例ALL患者的检查显示，在治疗第59天以及巩固期的两个时间点，tau蛋白有统计学意义的升高。在诊断后平均3.7年对19例患者的认知功能进行了检查。维持治疗开始时的tau水平与智力量表上测得的语言能力呈负相关。该研究表明，ALL标准治疗可能导致认知功能下降。
