Purnell D M, Kreider J W, Bartlett G L
J Natl Cancer Inst. 1975 Jul;55(1):123-8. doi: 10.1093/jnci/55.1.123.
The antitumor activity of three preparations of killed Bordetella pertussis (Bp) (Eli Lilly crude and fluid pertussis vaccines and Parke-Davis pertussis vaccine) was studied in the B16 melanoma and CaD2 mammary adenocarcinoma models. In these tumor systems; Bp had weak and variable tumor inhibitory activity and did not augment tumor rejection immunity. The intratumor injection of Bp did not affect the growth of the B16 tumor but significantly inhibited the growth of the CaD2 tumor. However, the established tumor did not regress. Admixture of Bp with B16 cells before inoculation inhibited tumor growth and prolonged survival of inoculated mice. Admixture of Bp with CaD2 cells completely suppressed tumor cell growth in 60% of inoculated mice. Intratumor injection of CaD2 with Bp combined with surgery provided no protection against subsequent development of metastases.
在B16黑色素瘤和CaD2乳腺腺癌模型中研究了三种百日咳博德特氏菌（Bp）灭活制剂（礼来粗制和液体百日咳疫苗以及帕克-戴维斯百日咳疫苗）的抗肿瘤活性。在这些肿瘤系统中，Bp具有微弱且多变的肿瘤抑制活性，并且不会增强肿瘤排斥免疫力。瘤内注射Bp对B16肿瘤的生长没有影响，但显著抑制了CaD2肿瘤的生长。然而，已形成的肿瘤并未消退。接种前将Bp与B16细胞混合可抑制肿瘤生长并延长接种小鼠的存活时间。将Bp与CaD2细胞混合可使60%的接种小鼠的肿瘤细胞生长完全受到抑制。瘤内注射CaD2与Bp并结合手术并不能预防随后转移灶的形成。
