Ventura Lori M, Sorokac Nancy, De Los Santos Roosevelt, Feuer William J, Porciatti Vittorio
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3904-11. doi: 10.1167/iovs.06-0161.
To compare relative reduction of retinal ganglion cell (RGC) function and retinal nerve fiber layer (RNFL) thickness in early glaucoma by means of steady-state pattern electroretinogram (PERG) and optical coherence tomography (OCT), respectively.
Eighty-four persons with suspected glaucoma due to disc abnormalities (GS: mean age 56.6 +/- 13.8 years, standard automated perimetry [SAP] mean deviation [MD] -0.58 +/- 1.34 dB) and 34 patients with early manifest glaucoma (EMG, mean age 65.9 +/- 10.7 years, SAP MD -2.7 +/- 4.5 dB) were tested with PERG and OCT. Both GS and EMG patients had small refractive errors, corrected visual acuity > or =20/25, and no systemic or retinal disease other than glaucoma.
MDs from age-predicted normal values were larger for PERG amplitude (GS: -1.113 dB; EMG: -2.352 dB) compared with the PERG-matched RNFL thickness (GS: -0.217 dB; EMG: -0.725 dB). Deviations exceeding the lower 95% tolerance intervals of the normal population were more frequent for PERG amplitude (GS: 26%; EMG: 56%) than PERG-matched RNFL thickness (GS: 6%; EMG: 29%).
In early glaucoma, reduction in RGC electrical activity exceeds the proportion expected from lost RGC axons, suggesting that a population of viable RGCs in the central retina is dysfunctional. By combining PERG and OCT it is, in principle, possible to obtain unique information on reduced responsiveness of viable RGCs.
分别通过稳态图形视网膜电图（PERG）和光学相干断层扫描（OCT）比较早期青光眼患者视网膜神经节细胞（RGC）功能和视网膜神经纤维层（RNFL）厚度的相对降低情况。
对84例因视盘异常而疑似青光眼的患者（GS组：平均年龄56.6±13.8岁，标准自动视野计[SAP]平均偏差[MD]为-0.58±1.34 dB）和34例早期显性青光眼患者（EMG组：平均年龄65.9±10.7岁，SAP MD为-2.7±4.5 dB）进行PERG和OCT检测。GS组和EMG组患者均有轻度屈光不正，矫正视力≥20/25，除青光眼外无全身性或视网膜疾病。
与PERG匹配的RNFL厚度相比（GS组：-0.217 dB；EMG组：-0.725 dB），PERG振幅偏离年龄预测正常值的MD更大（GS组：-1.113 dB；EMG组：-2.352 dB）。PERG振幅超过正常人群95%下限耐受区间的偏差比PERG匹配的RNFL厚度更常见（GS组：26%；EMG组：56%）（GS组：6%；EMG组：29%）。
在早期青光眼中，RGC电活动的降低超过了因RGC轴突丢失所预期的比例，这表明中央视网膜中一群存活的RGC功能失调。原则上，通过结合PERG和OCT，有可能获得关于存活RGC反应性降低的独特信息。
