Acton Ronald T, Barton James C, Passmore Leah V, Adams Paul C, Speechley Mark R, Dawkins Fitzroy W, Sholinsky Phyliss, Reboussin David M, McLaren Gordon D, Harris Emily L, Bent Thomas C, Vogt Thomas M, Castro Oswaldo
Department of Microbiology, University of Alabama at Birmingham, 1530 3rd Ave. South, Birmingham, AL 35294-0005, USA.
Diabetes Care. 2006 Sep;29(9):2084-9. doi: 10.2337/dc05-1592.
We evaluated the associations of self-reported diabetes with serum ferritin concentration, transferrin saturation (TfSat), and HFE C282Y and H63D mutations in six racial/ethnic groups recruited at five field centers in the Hemochromatosis and Iron Overload Screening (HEIRS) study.
Analyses were conducted on 97,470 participants. Participants who reported a previous diagnosis of diabetes and/or hemochromatosis or iron overload were compared with participants who did not report a previous diagnosis.
The overall prevalence of diabetes was 13.8%; the highest prevalence was in Pacific Islanders (20.1%). Of all participants with diabetes, 2.0% reported that they also had hemochromatosis or iron overload. The mean serum ferritin concentration was significantly greater in women with diabetes in all racial/ethnic groups and in Native-American men with diabetes than in those without diabetes. The mean serum ferritin concentration was significantly lower in Asian men with diabetes than in those without diabetes. Mean TfSat was lower in participants with diabetes from all racial/ethnic groups except Native-American women than in those without diabetes. There was no significant association of diabetes with HFE genotype. The mean serum ferritin concentration was greater (P < 0.0001) in women with diabetes than in those without diabetes for HFE genotypes except C282Y/C282Y and C282Y/H63D. Log serum ferritin concentration was significantly associated with diabetes in a logistic regression analysis after adjusting for age, sex, racial/ethnic group, HFE genotype, and field center.
Serum ferritin concentration is associated with diabetes, even at levels below those typically associated with hemochromatosis or iron overload.
在血色素沉着症和铁过载筛查（HEIRS）研究中，我们评估了自我报告的糖尿病与血清铁蛋白浓度、转铁蛋白饱和度（TfSat）以及HFE C282Y和H63D突变在五个现场中心招募的六个种族/族裔群体中的关联。
对97470名参与者进行了分析。将报告既往诊断为糖尿病和/或血色素沉着症或铁过载的参与者与未报告既往诊断的参与者进行比较。
糖尿病的总体患病率为13.8%；患病率最高的是太平洋岛民（20.1%）。在所有糖尿病参与者中，2.0%报告他们也患有血色素沉着症或铁过载。在所有种族/族裔群体中，患有糖尿病的女性以及患有糖尿病的美国原住民男性的平均血清铁蛋白浓度显著高于无糖尿病者。患有糖尿病的亚洲男性的平均血清铁蛋白浓度显著低于无糖尿病者。除美国原住民女性外，所有种族/族裔群体中患有糖尿病的参与者的平均TfSat均低于无糖尿病者。糖尿病与HFE基因型无显著关联。除C282Y/C282Y和C282Y/H63D外，HFE基因型中患有糖尿病的女性的平均血清铁蛋白浓度高于无糖尿病者（P<0.0001）。在调整年龄、性别、种族/族裔群体、HFE基因型和现场中心后，log血清铁蛋白浓度在逻辑回归分析中与糖尿病显著相关。
血清铁蛋白浓度与糖尿病相关，即使在低于通常与血色素沉着症或铁过载相关的水平时也是如此。
