Hung Chien-Ching, Hsiao Chin-Fu, Chen Mao-Yuan, Hsieh Szu-Min, Chang Sui-Yuan, Sheng Wang-Huei, Sun Hsin-Yun, Chang Shan-Chwen
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Jpn J Infect Dis. 2006 Aug;59(4):222-8.
We assessed the survival of 1,044 HIV-infected persons enrolled in three periods: period 1, 1994 to 1997 (before the introduction of highly active antiretroviral therapy [HAART]); period 2, 1997 to 2000 (early-HAART); and period 3, 2000 to 2004 (late-HAART). As of 30 June 2005, 259 (24.8%) persons had died after a median observation duration of 985 days (range, 2 - 4,025 days). The mortality rate declined from 33.75 per 100 person-years in the pre-HAART era to 6.51 per 100 person-years in the late-HAART era (P < 0.0001). The adjusted hazard ratios for death in persons with a baseline CD4 count of <200 cells/mul in periods 2 and 3 were 0.605 (P = 0.007) and 0.371 (P < 0.0001), respectively, when compared with persons enrolled in period 1; the adjusted hazard ratio for death was 0.611 for persons enrolled in period 3 when compared to period 2 (P = 0.01). Our study suggested that the survival of persons in the late stage of HIV infection in Taiwan continued to improve in the late HAART era.
我们评估了1044名HIV感染者的生存情况，这些感染者被纳入三个时间段：时间段1为1994年至1997年（在高效抗逆转录病毒治疗[HAART]引入之前）；时间段2为1997年至2000年（早期HAART）；时间段3为2000年至2004年（晚期HAART）。截至2005年6月30日，259人（24.8%）已经死亡，中位观察期为985天（范围为2至4025天）。死亡率从HAART治疗前时代的每100人年33.75例下降至晚期HAART时代的每100人年6.51例（P<0.0001）。与时间段1纳入的感染者相比，时间段2和3中基线CD4细胞计数<200个/μl的感染者死亡的调整风险比分别为0.605（P = 0.007）和0.371（P<0.0001）；与时间段2相比，时间段3纳入的感染者死亡的调整风险比为0.611（P = 0.01）。我们的研究表明，在台湾，晚期HAART时代HIV感染晚期患者的生存情况持续改善。
