Ferguson M, Minor P D
National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, U.K.
J Gen Virol. 1990 Jun;71 ( Pt 6):1271-4. doi: 10.1099/0022-1317-71-6-1271.
A panel of monoclonal antibodies which react with empty non-infectious type 3 poliovirus particles (C antigen) but not infectious virus (D antigen) were characterized for their reactivity with C antigen particles derived from neutralization-resistant virus strains which had single amino acid substitutions at each of the antigenic sites. Antibodies were identified which failed to bind to variant viruses with modifications at each of antigenic sites 2b, 3b and 4 indicating that the same amino acid sequences involved in the neutralization of infectious virus are also present on the surface of non-infectious particles but in different configurations.
一组单克隆抗体可与空的非感染性3型脊髓灰质炎病毒颗粒（C抗原）发生反应，但不与感染性病毒（D抗原）发生反应，对这些抗体与来自中和抗性病毒株的C抗原颗粒的反应性进行了表征，这些病毒株在每个抗原位点都有单个氨基酸替换。鉴定出的抗体无法与在抗原位点2b、3b和4均有修饰的变异病毒结合，这表明参与感染性病毒中和的相同氨基酸序列也存在于非感染性颗粒的表面，但构型不同。
