Warren K G, Catz I
Department of Medicine (Neurology), University of Alberta, Edmonton, Canada.
J Neurol Sci. 1990 Apr;96(1):19-27. doi: 10.1016/0022-510x(90)90053-p.
Immunoglobulin G (IgG) was purified by affinity chromatography from the CSF of multiple sclerosis (MS) patients and controls. In MS patients, the IgG fraction contains anti-myelin basic protein (anti-MBP), anti-MBP neutralizing antibody and an antibody which inhibits neutralization of anti-MBP. Anti-MBP was detected in patients with acute relapses, anti-MBP neutralizing antibody was present in patients in clinical remission and the inhibiting antibody was detected in patients with chronically progressing MS. A myelin basic protein antibody cascade could be involved in the mechanism of MS.
通过亲和层析从多发性硬化症（MS）患者和对照者的脑脊液中纯化免疫球蛋白G（IgG）。在MS患者中，IgG组分含有抗髓鞘碱性蛋白（抗MBP）、抗MBP中和抗体以及一种抑制抗MBP中和作用的抗体。在急性复发患者中检测到抗MBP，临床缓解患者中存在抗MBP中和抗体，而在慢性进展性MS患者中检测到抑制性抗体。髓鞘碱性蛋白抗体级联反应可能参与MS的发病机制。
