Legrand Dominique, Elass Elisabeth, Carpentier Mathieu, Mazurier Joël
Unité de Glycobiologie Structurale et Fonctionnelle et Unité Mixte de Recherche n 8576 du Centre National de la Recherche Scientifique, Université des Sciences et Technologies de Lille, France.
Biochem Cell Biol. 2006 Jun;84(3):282-90. doi: 10.1139/o06-045.
The antimicrobial activities of lactoferrin (Lf) depend on its capacity to bind iron and on its direct interaction with the surface of microorganisms. Its protective effect also extends to the regulation of the host response to infections. Depending on the immune status of an individual, Lf can have anti-inflammatory properties that downregulate the immune response and prevent septic shock and damage to tissues. It also acts as a promoter of the activation, differentiation, and (or) proliferation of immune cells. Although most of the anti-inflammatory activities are correlated with the neutralization of proinflammatory molecules by Lf, the promoting activity seems to be related to a direct effect of Lf on immune cells. Although the mechanisms that govern these activities are not clearly defined, and probably differ from cell to cell, several cellular targets and possible mechanisms of action are highlighted. The majority of the molecular targets at the surface of cells are multiligand receptors but, interestingly, most of them have been reported as signaling, endocytosis, and nuclear-targeting molecules. This review focuses on the known and putative mechanisms that allow the immunoregulating effect of Lf in its interactions with immune cells.
乳铁蛋白（Lf）的抗菌活性取决于其结合铁的能力以及与微生物表面的直接相互作用。其保护作用还扩展到对宿主感染反应的调节。根据个体的免疫状态，Lf可具有抗炎特性，下调免疫反应，预防脓毒症休克和组织损伤。它还作为免疫细胞激活、分化和（或）增殖的促进剂。虽然大多数抗炎活性与Lf对促炎分子的中和有关，但促进活性似乎与Lf对免疫细胞的直接作用有关。尽管控制这些活性的机制尚未明确界定，且可能因细胞而异，但仍突出了几个细胞靶点和可能的作用机制。细胞表面的大多数分子靶点是多配体受体，但有趣的是，其中大多数已被报道为信号传导、内吞作用和核靶向分子。本综述重点关注Lf在与免疫细胞相互作用中产生免疫调节作用的已知和推测机制。
