文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

脂质体乳铁蛋白对体外 HCoV-229E 和 SARS-CoV-2 假病毒具有抗病毒活性。

Liposomal Lactoferrin Exerts Antiviral Activity against HCoV-229E and SARS-CoV-2 Pseudoviruses In Vitro.

机构信息

Department of Molecular Biology, Universidad Autónoma de Madrid, C/Darwin, 2 Cantoblanco, 28049 Madrid, Spain.

Centro de Biología Molecular Severo Ochoa, Spanish National Research Council-Universidad Autónoma de Madrid (CSIC-UAM), C/Nicolás Cabrera, 1 Cantoblanco, 28049 Madrid, Spain.

出版信息

Viruses. 2023 Apr 15;15(4):972. doi: 10.3390/v15040972.

DOI:10.3390/v15040972
PMID:37112952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10142420/
Abstract

A limited number of effective therapies are currently available to treat human coronavirus SARS-CoV-2 and other human coronaviruses, which are responsible for nearly a third of global cases of the common cold. The possibility of new emerging coronaviruses demands powerful new antiviral strategies. Lactoferrin is a well-known protein that possesses anti-inflammatory and immunomodulatory activities, and it has previously shown antiviral activity against several viruses, including SARS-CoV-2. To increase this antiviral activity, here we present bovine liposomal lactoferrin. Liposomal encapsulation of the compound was proven to increase permeability, bioavailability, and time release. In the present work, we compare the antiviral activity of free and liposomal bovine lactoferrin against HCoV229E and SARS-CoV-2 in vitro and in human primary bronchial epithelial cells, and we demonstrated that the liposomal form exerts a more potent antiviral activity than its free form at non-cytotoxic doses.

摘要

目前，仅有有限数量的有效疗法可用于治疗人类冠状病毒 SARS-CoV-2 和其他人类冠状病毒，这些病毒导致了近三分之一的普通感冒全球病例。新出现的冠状病毒的可能性需要强大的新抗病毒策略。乳铁蛋白是一种众所周知的蛋白质，具有抗炎和免疫调节活性，并且先前已显示对多种病毒（包括 SARS-CoV-2）具有抗病毒活性。为了提高这种抗病毒活性，我们在这里提出了牛脂膜乳铁蛋白。已证明该化合物的脂膜包封可增加通透性、生物利用度和时间释放。在本工作中，我们比较了游离和脂膜牛乳铁蛋白对 HCoV229E 和 SARS-CoV-2 的体外和人原代支气管上皮细胞中的抗病毒活性，并证明脂膜形式在非细胞毒性剂量下比游离形式发挥更强的抗病毒活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/0bb52e54008d/viruses-15-00972-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/ab1e737ee51b/viruses-15-00972-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/61c9a02f0cb5/viruses-15-00972-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/b515664c68c5/viruses-15-00972-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/0bb52e54008d/viruses-15-00972-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/ab1e737ee51b/viruses-15-00972-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/61c9a02f0cb5/viruses-15-00972-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/b515664c68c5/viruses-15-00972-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/0bb52e54008d/viruses-15-00972-g004.jpg

相似文献

[1]
Liposomal Lactoferrin Exerts Antiviral Activity against HCoV-229E and SARS-CoV-2 Pseudoviruses In Vitro.

Viruses. 2023-4-15

[2]
The antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor.

Emerg Microbes Infect. 2021-12

[3]
Effect of Jinzhen granule on two coronaviruses: The novel SARS-CoV-2 and the HCoV-229E and the evidences for their mechanisms of action.

Phytomedicine. 2022-1

[4]
Assessment of Antiviral Coatings for High-Touch Surfaces by Using Human Coronaviruses HCoV-229E and SARS-CoV-2.

Appl Environ Microbiol. 2021-9-10

[5]
Inactivation of SARS-CoV-2 and HCoV-229E in vitro by ColdZyme® a medical device mouth spray against the common cold.

J Med Virol. 2021-3

[6]
Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system.

Antiviral Res. 2021-3

[7]
Luteolin Isolated from L., a Potential Remedy for Human Coronavirus 229E.

Molecules. 2023-5-23

[8]
Lichen or Associated Micro-Organism Compounds Are Active against Human Coronaviruses.

Viruses. 2023-8-31

[9]
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitro.

Virus Res. 2022-11

[10]
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 and a Promising Oral Antiviral for Treatment of COVID-19.

Antimicrob Agents Chemother. 2021-3-18

引用本文的文献

[1]
Inhibition of Human Coronavirus 229E by Lactoferrin-Derived Peptidomimetics.

Pharmaceutics. 2025-8-1

[2]
Lactoferrin: Properties and Potential Uses in the Food Industry.

Int J Mol Sci. 2025-2-7

[3]
Lactoferrin exhibits PEDV antiviral activity by interfering with spike-heparan sulfate proteoglycans binding and activating mucosal immune response.

Vet Res. 2025-1-31

[4]
Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture.

Nanomaterials (Basel). 2024-12-16

[5]
Is there sufficient evidence to support the health benefits of including donkey milk in the diet?

Front Nutr. 2024-9-25

[6]
Optimization of Cellular Transduction by the HIV-Based Pseudovirus Platform with Pan-Coronavirus Spike Proteins.

Viruses. 2024-9-20

[7]
Lactoferrin: A Promising Therapeutic Molecule against Human Papillomavirus.

Nutrients. 2024-9-12

[8]
Comparative In Vitro Study between Biocompatible Chitosan-Based Magnetic Nanocapsules and Liposome Formulations with Potential Application in Anti-Inflammatory Therapy.

Int J Mol Sci. 2024-8-2

[9]
Combination of Nanodelivery Systems and Constituents Derived from Novel Foods: A Comprehensive Review.

Pharmaceutics. 2023-11-11

本文引用的文献

[1]
Can Lactoferrin, a Natural Mammalian Milk Protein, Assist in the Battle against COVID-19?

Nutrients. 2022-12-10

[2]
Lactoferrin for COVID-19 prevention, treatment, and recovery.

Front Nutr. 2022-11-7

[3]
Molecular mimicry of the receptor-binding domain of the SARS-CoV-2 spike protein: from the interaction of spike-specific antibodies with transferrin and lactoferrin to the antiviral effects of human recombinant lactoferrin.

Biometals. 2023-6

[4]
Bovine lactoferrin inhibits SARS-CoV-2 and SARS-CoV-1 by targeting the RdRp complex and alleviates viral infection in the hamster model.

J Med Virol. 2023-1

[5]
Lactoferrin Binding to SARS-CoV-2 Spike Glycoprotein Blocks Pseudoviral Entry and Relieves Iron Protein Dysregulation in Several In Vitro Models.

Pharmaceutics. 2022-10-3

[6]
New Properties of a Well-Known Antioxidant: Pleiotropic Effects of Human Lactoferrin in Mice Exposed to Gamma Irradiation in a Sublethal Dose.

Antioxidants (Basel). 2022-9-18

[7]
Ferristatin II Efficiently Inhibits SARS-CoV-2 Replication in Vero Cells.

Viruses. 2022-2-3

[8]
A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives.

Molecules. 2022-2-17

[9]
Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry Perspective.

Molecules. 2022-1-20

[10]
Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells.

PLoS Pathog. 2022-1

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索