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脂质体乳铁蛋白对体外 HCoV-229E 和 SARS-CoV-2 假病毒具有抗病毒活性。

Liposomal Lactoferrin Exerts Antiviral Activity against HCoV-229E and SARS-CoV-2 Pseudoviruses In Vitro.

机构信息

Department of Molecular Biology, Universidad Autónoma de Madrid, C/Darwin, 2 Cantoblanco, 28049 Madrid, Spain.

Centro de Biología Molecular Severo Ochoa, Spanish National Research Council-Universidad Autónoma de Madrid (CSIC-UAM), C/Nicolás Cabrera, 1 Cantoblanco, 28049 Madrid, Spain.

出版信息

Viruses. 2023 Apr 15;15(4):972. doi: 10.3390/v15040972.

DOI:10.3390/v15040972
PMID:37112952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10142420/
Abstract

A limited number of effective therapies are currently available to treat human coronavirus SARS-CoV-2 and other human coronaviruses, which are responsible for nearly a third of global cases of the common cold. The possibility of new emerging coronaviruses demands powerful new antiviral strategies. Lactoferrin is a well-known protein that possesses anti-inflammatory and immunomodulatory activities, and it has previously shown antiviral activity against several viruses, including SARS-CoV-2. To increase this antiviral activity, here we present bovine liposomal lactoferrin. Liposomal encapsulation of the compound was proven to increase permeability, bioavailability, and time release. In the present work, we compare the antiviral activity of free and liposomal bovine lactoferrin against HCoV229E and SARS-CoV-2 in vitro and in human primary bronchial epithelial cells, and we demonstrated that the liposomal form exerts a more potent antiviral activity than its free form at non-cytotoxic doses.

摘要

目前，仅有有限数量的有效疗法可用于治疗人类冠状病毒 SARS-CoV-2 和其他人类冠状病毒，这些病毒导致了近三分之一的普通感冒全球病例。新出现的冠状病毒的可能性需要强大的新抗病毒策略。乳铁蛋白是一种众所周知的蛋白质，具有抗炎和免疫调节活性，并且先前已显示对多种病毒（包括 SARS-CoV-2）具有抗病毒活性。为了提高这种抗病毒活性，我们在这里提出了牛脂膜乳铁蛋白。已证明该化合物的脂膜包封可增加通透性、生物利用度和时间释放。在本工作中，我们比较了游离和脂膜牛乳铁蛋白对 HCoV229E 和 SARS-CoV-2 的体外和人原代支气管上皮细胞中的抗病毒活性，并证明脂膜形式在非细胞毒性剂量下比游离形式发挥更强的抗病毒活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/0bb52e54008d/viruses-15-00972-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/ab1e737ee51b/viruses-15-00972-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/61c9a02f0cb5/viruses-15-00972-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/b515664c68c5/viruses-15-00972-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/0bb52e54008d/viruses-15-00972-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/ab1e737ee51b/viruses-15-00972-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/61c9a02f0cb5/viruses-15-00972-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/b515664c68c5/viruses-15-00972-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72d5/10142420/0bb52e54008d/viruses-15-00972-g004.jpg

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