血根碱和白屈菜红碱对细胞周期及细胞凋亡的影响。
Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis.
作者信息
Malikova Jana, Zdarilova Adela, Hlobilkova Alice
机构信息
Laboratory of Molecular Pathology and Institute of Pathology, Faculty of Medicine, Palacký University, Olomouc, Czech Republic.
出版信息
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):5-12. doi: 10.5507/bp.2006.001.
OBJECTIVES
This review summarizes the involvement of sanguinarine and chelerythrine in cell cycle regulation and cell death in various cell lines. It is focused on their potential in the treatment of cancer.
METHODS
We conducted a search of PubMed, ScienceDirect and Medline for papers on the molecular mechanisms of the biological activity of sanguinarine and chelerythrine published mainly from 1995 to 2006.
RESULTS AND CONCLUSIONS
Our analysis of the published studies suggested that these alkaloids are not only good candidates for chemotherapeutic regimens but may also contribute to the development of successful immune therapies of some carcinomas due to their apoptotic potential. However, the complete signalling cascade in which sanguinarine and chelerythrine treatment induces apoptotic cell death is not yet understood. Overall, the results of recent studies suggest that sanguinarine and chelerythrine may be useful as agents in the management of cancer.
目的
本综述总结了血根碱和白屈菜红碱在各种细胞系中对细胞周期调控和细胞死亡的影响。重点关注它们在癌症治疗中的潜力。
方法
我们在PubMed、ScienceDirect和Medline上搜索了主要发表于1995年至2006年的关于血根碱和白屈菜红碱生物活性分子机制的论文。
结果与结论
我们对已发表研究的分析表明，这些生物碱不仅是化疗方案的良好候选药物，而且由于其诱导凋亡的潜力，还可能有助于某些癌症成功免疫治疗的发展。然而，血根碱和白屈菜红碱治疗诱导凋亡性细胞死亡的完整信号级联尚未明确。总体而言，近期研究结果表明血根碱和白屈菜红碱可能作为癌症治疗药物有用。
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