Paparrigopoulos Thomas, Liappas John, Tzavellas Elias, Mourikis Iraklis, Soldatos Constantin
Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Vas. Sofias Ave. 115 28 Athens, Greece.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):92-6. doi: 10.1016/j.pnpbp.2006.07.006. Epub 2006 Aug 28.
Although amisulpride is considered to be a prolactin-raising atypical antipsychotic drug, a limited number of studies have documented the extent of its prolactin-elevating properties. In the present study the effect of amisulpride on plasma levels of prolactin and the reversibility of this untoward side effect were investigated.
17 patients with various diagnoses received amisulpride (50-800 mg/day) or a combination of amisulpride plus other medication as needed. Plasma prolactin was determined 26.7+/-9.4 days (range: 13-50 days) after initiation of treatment and in 3 cases after a much longer period, and 14-51 days following its withdrawal.
All patients on amisulpride had hyperprolactinemia (mean+/-S.D. prolactin levels: 62.5+/-33.0 ng/ml) with females exhibiting considerably higher prolactin levels than males. Following amisulpride discontinuation prolactin levels were significantly (p<000) reduced (mean+/-S.D. prolactin levels: 12.3+/-6.7 ng/ml). No significant correlation was detected between prolactin levels and either amisulpride dosage or duration of administration.
Amisulpride has a pronounced prolactin-elevating effect which appears to be independent of dosage and duration of administration. Hyperprolactinemia rapidly reverses following amisulpride discontinuation.
尽管氨磺必利被认为是一种可升高催乳素的非典型抗精神病药物，但仅有有限的研究记录了其升高催乳素特性的程度。在本研究中，对氨磺必利对催乳素血浆水平的影响以及这种不良副作用的可逆性进行了调查。
17例患有各种诊断疾病的患者接受了氨磺必利（50 - 800毫克/天）或根据需要联合使用氨磺必利加其他药物。在开始治疗后26.7±9.4天（范围：13 - 50天）以及3例更长时间后，以及停药后14 - 51天测定血浆催乳素。
所有服用氨磺必利的患者均出现高催乳素血症（平均±标准差催乳素水平：62.5±33.0纳克/毫升），女性的催乳素水平明显高于男性。停用氨磺必利后，催乳素水平显著降低（p<0.00）（平均±标准差催乳素水平：12.3±6.7纳克/毫升）。未检测到催乳素水平与氨磺必利剂量或给药持续时间之间存在显著相关性。
氨磺必利具有明显的催乳素升高作用，这似乎与剂量和给药持续时间无关。停用氨磺必利后，高催乳素血症迅速逆转。
