Bargiota S I, Bonotis K S, Messinis I E, Angelopoulos N V
Department of Psychiatry, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece.
Department of Obstetrics and Gynecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece.
Schizophr Res Treatment. 2013;2013:502697. doi: 10.1155/2013/502697. Epub 2013 Dec 24.
Introduction. Typical and atypical antipsychotic agent is currently used for treatment in the majority of patients with psychotic disorders. The aim of this review is to assess antipsychotic induced hyperprolactinaemia and the following menstrual dysfunction that affects fertility, quality of life, and therapeutic compliance of women. Method. For this purpose, Medline, PsychInfo, Cochrane library, and Scopus databases were accessed, with a focus on the publication dates between 1954 and 2012. Research of references was also performed and 78 studies were retrieved and used for the needs of this review. Results. A summary of several antipsychotics as well as frequency rates and data on hyperprolactinaemia and menstrual disorders for different agent is presented. Conclusion. Diverse prevalence rates of hyperprolactinaemia and menstrual abnormalities have been found about each medication among different studies. Menstruation plays an important role for women, thus, understanding, careful assessment, and management of hyperprolactinaemia could enhance their lives, especially when dealing with women that suffer from a psychotic disorder.
引言。目前，典型和非典型抗精神病药物被广泛用于治疗大多数精神障碍患者。本综述的目的是评估抗精神病药物所致高催乳素血症以及随之而来的月经功能障碍，这些问题会影响女性的生育能力、生活质量和治疗依从性。方法。为此，检索了Medline、PsychInfo、Cochrane图书馆和Scopus数据库，重点关注1954年至2012年之间的出版日期。还进行了参考文献检索，共检索到78项研究并用于本综述。结果。列出了几种抗精神病药物的概述以及不同药物的高催乳素血症和月经紊乱的发生率及数据。结论。不同研究中每种药物的高催乳素血症和月经异常的患病率各不相同。月经对女性至关重要，因此，了解、仔细评估和管理高催乳素血症可以改善她们的生活，尤其是在治疗患有精神障碍的女性时。
