Chadwick Wayne Anthony, Roux Saartjie, van de Venter Maryna, Louw Johan, Oelofsen Willem
Nelson Mandela Metropolitan University of Port Elizabeth, Department of Biochemistry and Microbiology, Summerstrand, South Campus, Port Elizabeth 6031, Eastern Province, South Africa.
J Ethnopharmacol. 2007 Jan 3;109(1):121-7. doi: 10.1016/j.jep.2006.07.012. Epub 2006 Jul 22.
Sutherlandia frutescens has been marked as a potential hypoglycaemic agent for the treatment of type 2 diabetes. We investigated the effects of Sutherlandia frutescens in bringing about hypoglycaemia and promoting glucose uptake in pre-diabetic rats. Crushed Sutherlandia frutescens leaves in drinking water were administered to rats fed a high fat diet. Positive control rats received only metformin. Glucose uptake experiments were undertaken using [(3)H] deoxy-glucose. Various physiological parameters were also measured. Rats receiving Sutherlandia frutescens displayed normoinsulinaemic levels, after 8 weeks medicational compliance, compared to the fatty controls. There was a significant increase in glucose uptake into muscle and adipose tissue, and a significant decrease in intestinal glucose uptake (p<0.001 at 60min) in rats receiving the plant extract. The Sutherlandia frutescens plant extract shows promise as a type 2 anti-diabetes medication because of its ability to normalize insulin levels and glucose uptake in peripheral tissues and suppress intestinal glucose uptake, with no weight gain noted. The exact mechanism of action and the extract's efficacy in humans need further confirmation.
南非半边莲已被认定为一种治疗2型糖尿病的潜在降血糖药物。我们研究了南非半边莲对糖尿病前期大鼠产生低血糖和促进葡萄糖摄取的影响。将碾碎的南非半边莲叶子加入饮用水中，喂给高脂饮食的大鼠。阳性对照大鼠仅接受二甲双胍。使用[³H]脱氧葡萄糖进行葡萄糖摄取实验。还测量了各种生理参数。与高脂肪对照组相比，接受南非半边莲治疗8周后，大鼠的胰岛素水平正常。接受植物提取物的大鼠肌肉和脂肪组织中的葡萄糖摄取显著增加，肠道葡萄糖摄取显著减少（60分钟时p<0.001）。南非半边莲植物提取物有望成为一种2型抗糖尿病药物，因为它能够使外周组织中的胰岛素水平和葡萄糖摄取正常化，并抑制肠道葡萄糖摄取，且未观察到体重增加。其确切作用机制以及该提取物在人体中的疗效需要进一步证实。
