脂质异常在1型和2型糖尿病青少年中普遍存在：青少年糖尿病研究（SEARCH）。

Lipid abnormalities are prevalent in youth with type 1 and type 2 diabetes: the SEARCH for Diabetes in Youth Study.

作者信息

Kershnar Ann K, Daniels Stephen R, Imperatore Giuseppina, Palla Shana L, Petitti Diana B, Pettitt David J, Marcovina Santica, Dolan Lawrence M, Hamman Richard F, Liese Angela D, Pihoker Catherine, Rodriguez Beatriz L

机构信息

Research and Evaluation, Kaiser Permanente Southern California, 9449 East Imperial Highway, Downey, CA 90242, USA.

出版信息

J Pediatr. 2006 Sep;149(3):314-9. doi: 10.1016/j.jpeds.2006.04.065.

DOI:10.1016/j.jpeds.2006.04.065

PMID:16939739

Abstract

OBJECTIVE

Assessment of the prevalence of serum lipid abnormalities in US youth with type 1 or type 2 diabetes.

STUDY DESIGN

The SEARCH for Diabetes in Youth Study was a cross-sectional, population-based study, conducted in six centers. Subjects were 2448 youth with diabetes who had a study examination. Outcome measures were fasting measures of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and non-HDL-C. Analysis was descriptive.

RESULTS

The overall prevalence of high TC concentration (>240 mg/dL) was 5%; the overall prevalence of high LDL-C (>160 mg/dL) was 3%, and the overall prevalence of high triglyceride (>400 mg/dL) was 2%. About half of the participants (48%) had an LDL-C concentration above the optimal level of 100 mg/dL. Among youth ages 10+, the prevalence of abnormal lipids was higher in type 2 (n = 283) than in type 1 diabetes (n = 1963): 33% versus 19% had TC concentration >200 mg/dL; 24% versus 15% had LDL-C concentration >130 mg/dL; 29% versus 10% had triglyceride concentration >150 mg/dL; 44% versus 12% had HDL-C concentration <40 mg/dL. Only 1% of youth were receiving pharmacologic therapy for dyslipidemia.

CONCLUSIONS

A substantial proportion of young patients with diabetes have abnormal serum lipids.

摘要

目的

评估美国1型或2型糖尿病青少年血清脂质异常的患病率。

研究设计

“青少年糖尿病研究”（SEARCH for Diabetes in Youth Study）是一项在六个中心开展的基于人群的横断面研究。研究对象为2448名接受了研究检查的糖尿病青少年。观察指标为空腹总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯和非HDL-C的测量值。分析采用描述性分析。

结果

高TC浓度（>240mg/dL）的总体患病率为5%；高LDL-C（>160mg/dL）的总体患病率为3%，高甘油三酯（>400mg/dL）的总体患病率为2%。约一半的参与者（48%）的LDL-C浓度高于100mg/dL的最佳水平。在10岁及以上的青少年中，2型糖尿病患者（n = 283）的血脂异常患病率高于1型糖尿病患者（n = 1963）：TC浓度>200mg/dL的患病率分别为33%和19%；LDL-C浓度>130mg/dL的患病率分别为24%和15%；甘油三酯浓度>150mg/dL的患病率分别为29%和10%；HDL-C浓度<40mg/dL的患病率分别为44%和12%。只有1%的青少年接受了血脂异常的药物治疗。