Tonelli Marcello, Klarenbach Scott, Manns Braden, Culleton Bruce, Hemmelgarn Brenda, Bertazzon Stefania, Wiebe Natasha, Gill John S
Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, Alta.
CMAJ. 2006 Aug 29;175(5):478-82. doi: 10.1503/cmaj.051356.
In a universal, public health care system, access to kidney transplantation should not be influenced by residence location. We determined the likelihood of kidney transplantation from deceased donors among Canadian dialysis patients living in 7 geographic regions. Within each region we also determined whether distance from the closest transplant centre was associated with the likelihood of transplantation.
A random sample of 7034 subjects initiating dialysis in Canada between 1996 and 2000 was studied. We used Cox proportional hazards models to examine the relation between residence location and the likelihood of kidney transplantation from deceased donors over a median period of 2.4 years.
There were significant differences in the likelihood of kidney transplantation from deceased donors and predicted waiting times between the different geographic regions. For example, the adjusted relative likelihood of transplantation in Alberta was 3.74 (95% confidence interval [CI] 2.95-4.76) compared with the likelihood in Ontario (p < 0.001). These differences persisted after further adjustment for differences in the rate of deceased organ donation. Within regions, patients who resided 50.1-150 km, 150.1-300 km and more than 300 km from the closest transplant centre had a similar adjusted likelihood of receiving a kidney transplant as those who lived less than 50 km away.
The adjusted likelihood of undergoing a kidney transplant from a deceased donor varied substantially between geographic regions in Canada. In contrast, the likelihood of transplantation within regions was not affected by distance from the closest transplant centre.
在全民公共医疗保健系统中,肾脏移植的可及性不应受居住地点的影响。我们确定了居住在加拿大7个地理区域的透析患者接受已故捐赠者肾脏移植的可能性。在每个区域内,我们还确定了与最近移植中心的距离是否与移植可能性相关。
对1996年至2000年期间在加拿大开始透析的7034名受试者进行随机抽样研究。我们使用Cox比例风险模型来检验居住地点与在中位时间2.4年内接受已故捐赠者肾脏移植可能性之间的关系。
不同地理区域在接受已故捐赠者肾脏移植的可能性和预测等待时间方面存在显著差异。例如,艾伯塔省的调整后移植相对可能性为3.74(95%置信区间[CI]2.95 - 4.76),而安大略省为(p < 0.001)。在对已故器官捐赠率差异进行进一步调整后,这些差异仍然存在。在各区域内,居住在距离最近移植中心50.1 - 150公里、150.1 - 300公里和超过300公里的患者,其接受肾脏移植的调整后可能性与居住在距离移植中心不到50公里的患者相似。
在加拿大,不同地理区域接受已故捐赠者肾脏移植的调整后可能性差异很大。相比之下,各区域内的移植可能性不受与最近移植中心距离的影响。