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拓扑异构酶II关卡：调控有丝分裂的通用机制。

Topoisomerase II checkpoints: universal mechanisms that regulate mitosis.

作者信息

Clarke Duncan J, Vas Amit C, Andrews Catherine A, Díaz-Martínez Laura A, Giménez-Abián Juan F

机构信息

Department of Genetics, Cell Biology & Development, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.

出版信息

Cell Cycle. 2006 Sep;5(17):1925-8. doi: 10.4161/cc.5.17.3200. Epub 2006 Sep 1.

DOI:10.4161/cc.5.17.3200
PMID:16940751
Abstract

Checkpoint controls confer order to the cell cycle and help prevent genome instability. Here we discuss the Topoisomerase II (Decatenation) Checkpoint which functions to regulate mitotic progression so that chromosomes can be efficiently condensed in prophase and can be segregated with high fidelity in anaphase.

摘要

关卡控制赋予细胞周期秩序，并有助于防止基因组不稳定。在此，我们讨论拓扑异构酶II（解连环）关卡，其功能是调节有丝分裂进程，以便染色体在前期能够有效地浓缩，并在后期能够以高保真度分离。

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