Makedos Georgios, Papanicolaou Alexis, Hitoglou Areti, Kalogiannidis Ioannis, Makedos Anastasios, Vrazioti Violeta, Goutzioulis Michalis
4th Department of Obstetrics and Gynecology, Aristotles University of Thessaloniki, 38 Mavromichali str, 54248 Thessaloniki, Greece.
Arch Gynecol Obstet. 2007 Feb;275(2):121-4. doi: 10.1007/s00404-006-0223-2. Epub 2006 Aug 29.
Elevated plasma homocysteine has been implicated in vascular changes compatible with atherosis and endothelial dysfunction similar to the vascular changes of the placenta in preeclampsia. Previous reports have indicated an increased incidence of hyperohomocysteinemia in preeclamptic patients. The aim of this study was to examine the association of homocysteine levels and preeclampsia in our patients.
Prospective study of 28 preeclamptic patients that were matched with 26 normal controls of the same gestational age.
The preeclamptic group had an increased incidence of cesarean sections (75%), of growth retarded fetuses (50%), intrauterine deaths (7%) and placental abruptions (7%). Mean levels of homocysteine were significantly elevated in the preeclamptic than in control group (11.11 vs. 6.40 micromol/l, P < 0.001). There were no differences between the groups regarding the levels of folic acid (11.12 vs. 9.73 ng/ml, P = 0.55) and vitamin B12 (295.76 vs. 356.15 pg/ml, P = 0.43).
It is concluded that in our study homocysteine levels are significantly elevated in patients with preeclampsia compared with control group, while no vitamin deficiencies were observed.
血浆同型半胱氨酸水平升高与动脉粥样硬化及内皮功能障碍相关的血管变化有关，这些变化类似于先兆子痫患者胎盘的血管变化。既往报道显示，先兆子痫患者高同型半胱氨酸血症的发生率增加。本研究的目的是探讨我们的患者中同型半胱氨酸水平与先兆子痫之间的关联。
对28例先兆子痫患者进行前瞻性研究，并与26例相同孕周的正常对照者进行匹配。
先兆子痫组剖宫产率（75%）、胎儿生长受限率（50%）、宫内死亡率（7%）和胎盘早剥率（7%）均增加。先兆子痫组同型半胱氨酸的平均水平显著高于对照组（11.11对6.40微摩尔/升，P<0.001）。两组之间叶酸水平（11.12对9.73纳克/毫升，P=0.55）和维生素B12水平（295.76对356.15皮克/毫升，P=0.43）无差异。
本研究得出结论，与对照组相比，先兆子痫患者的同型半胱氨酸水平显著升高，且未观察到维生素缺乏。
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