Wright A L, Bleehen S S, Champion A E
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK.
Dermatologica. 1990;180(4):255-7. doi: 10.1159/000248042.
An unusual case of extensive reticulate pigmentation due to bleomycin is reported. Light- and electron-microscopic studies showed a marked increase of melanin pigment in the basal keratinocytes and a number of melanophages in the upper dermis. The number of melanocytes appeared to be normal. Electron microscopy also revealed damage to subcellular organelles. The increase in pigmentation is thought to be a consequence of this focal damage.
报告了一例因博来霉素导致广泛网状色素沉着的罕见病例。光镜和电镜研究显示，基底角质形成细胞中黑色素明显增多，真皮上层有大量噬黑素细胞。黑素细胞数量似乎正常。电镜还显示亚细胞器受损。色素沉着增加被认为是这种局灶性损伤的结果。
