Satake K, Yamamoto T, Umeyama K
First Department of Surgery, Osaka City University Medical School, Japan.
Gastroenterol Jpn. 1990 Jun;25(3):376-82. doi: 10.1007/BF02779454.
This study reports the serial histologic changes of the healing process of relapsing edematous and hemorrhagic acute pancreatitis induced in rats by the close duodenal loop. Serum amylase levels in single, second and third attacks of edematous acute pancreatitis, and single and second attacks of hemorrhagic acute pancreatitis were elevated significantly compared with that of preligation levels (P less than 0.01), but the concentrations were similar in the five groups. However, the histologic findings were different. The results showed that repeated attacks may lead to more obvious damage to the pancreas compared with the first attack of either edematous or hemorrhagic acute pancreatitis. After elimination of causal factors the single attack of edematous acute pancreatitis healed completely but the destructive and hemorrhagic acute pancreatitis usually healed with scarring. Repeated attacks of edematous acute pancreatitis may lead to more chronic pancreatic damage and repeated attacks of destructive and hemorrhagic acute pancreatitis healed with more chronic pancreatic damage than that of repeated attacks of edematous acute pancreatitis.
本研究报告了通过十二指肠紧密环扎诱导大鼠复发性水肿性和出血性急性胰腺炎愈合过程中的系列组织学变化。与结扎前水平相比，水肿性急性胰腺炎单次、第二次和第三次发作以及出血性急性胰腺炎单次和第二次发作时的血清淀粉酶水平显著升高（P<0.01），但五组中的浓度相似。然而，组织学结果有所不同。结果表明，与水肿性或出血性急性胰腺炎的首次发作相比，反复发作对胰腺的损伤可能更明显。消除病因后，水肿性急性胰腺炎的单次发作可完全愈合，但坏死性和出血性急性胰腺炎通常会留下瘢痕愈合。水肿性急性胰腺炎的反复发作可能导致更慢性的胰腺损伤，坏死性和出血性急性胰腺炎的反复发作比水肿性急性胰腺炎的反复发作愈合时伴有更慢性的胰腺损伤。
