Kinami Y, Kita I
Department of Surgery II, Kanazawa Medical University, Ishikawa-Ken, Japan.
Int J Pancreatol. 1989 May;4(4):371-81. doi: 10.1007/BF02938473.
To clarify the relationship between changes in serum pancreatic enzymes and pathological changes in pancreatic parenchyma, this study was performed by using rat models with acute pancreatitis. The models were rats with edematous and necrotizing pancreatitis. Amylase, lipase, ribonuclease (RNase), and deoxyribonuclease (DNase I, II) in the serum were determined for 48 h after the development of pancreatitis. Amylase and lipase levels rose directly in both pancreatitis groups. These enzymes in the necrotizing pancreatitis group were higher than those in the edematous pancreatitis group, but there was no significant difference. RNase levels also rose markedly, but there was no obvious difference between either of the pancreatitis groups. On the other hand, DNase levels were high in the necrotizing pancreatitis group but low in the edematous pancreatitis group, with significant differences between the two groups, especially in the DNase II levels over a 36-h period (p less than 0.05-0.01). Therefore, these results suggest that serum DNase levels reveal the necrotizing changes in pancreatic parenchyma.
为阐明血清胰酶变化与胰腺实质病理改变之间的关系，本研究采用急性胰腺炎大鼠模型进行。模型为水肿性和坏死性胰腺炎大鼠。在胰腺炎发病后48小时测定血清中的淀粉酶、脂肪酶、核糖核酸酶（RNase）和脱氧核糖核酸酶（DNase I、II）。两个胰腺炎组的淀粉酶和脂肪酶水平均直接升高。坏死性胰腺炎组的这些酶高于水肿性胰腺炎组，但无显著差异。RNase水平也显著升高，但两个胰腺炎组之间无明显差异。另一方面，坏死性胰腺炎组的DNase水平高，而水肿性胰腺炎组的DNase水平低，两组之间有显著差异，尤其是在36小时内的DNase II水平（p小于0.05 - 0.01）。因此，这些结果表明血清DNase水平可反映胰腺实质的坏死性改变。
