前列腺素对心房和心室组织中肾上腺素能神经传递的不同作用。

Different effects of prostaglandins on adrenergic neurotransmission in atrial and ventricular preparations.

作者信息

Mantelli L, Amerini S, Ledda F

机构信息

Department of Pharmacology, University of Florence, Firenze, Italy.

出版信息

Br J Pharmacol. 1990 Apr;99(4):717-20. doi: 10.1111/j.1476-5381.1990.tb12995.x.

DOI:10.1111/j.1476-5381.1990.tb12995.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1917569/

Abstract

The effects of prostaglandin E2 (PGE2) and iloprost on the cardiac response to adrenergic nerve stimulation in guinea-pig atrial and ventricular preparations have been studied. 2. In guinea-pig isolated atria both PGE2 (0.1-10 nM) and iloprost (0.1-3 microM) concentration-dependently reduced the cardiac response to adrenergic nerve stimulation. 3. The inhibition of cyclo-oxygenase by indomethacin and acetylsalicylic acid potentiated the response to nerve stimulation in the atrial preparations. 4. Arachidonic acid (1-10 microM) reduced the response to nerve stimulation in atria. This effect was prevented by indomethacin and acetylsalicylic acid. 5. In guinea-pig ventricles PGE2 and iloprost were found to be effective at higher concentrations than in atrial preparations: arachidonic acid, indomethacin or acetylsalicylic acid did not modify the cardiac response to adrenergic nerve stimulation. 6. These results suggest a different modulator role for endogenous prostaglandins in atrial and ventricular tissue.

摘要

研究了前列腺素E2（PGE2）和伊洛前列素对豚鼠心房和心室标本中肾上腺素能神经刺激所致心脏反应的影响。2. 在豚鼠离体心房中，PGE2（0.1 - 10 nM）和伊洛前列素（0.1 - 3 microM）均浓度依赖性地降低了对肾上腺素能神经刺激的心脏反应。3. 吲哚美辛和乙酰水杨酸对环氧化酶的抑制作用增强了心房标本中对神经刺激的反应。4. 花生四烯酸（1 - 10 microM）降低了心房中对神经刺激的反应。吲哚美辛和乙酰水杨酸可阻止这种作用。5. 在豚鼠心室中，发现PGE2和伊洛前列素在高于心房标本的浓度时才有效：花生四烯酸、吲哚美辛或乙酰水杨酸并未改变对肾上腺素能神经刺激的心脏反应。6. 这些结果表明内源性前列腺素在心房和心室组织中具有不同的调节作用。