Cohen Seth M, Garrett C Gaelyn, Dupont William D, Ossoff Robert H, Courey Mark S
Vanderbilt Voice Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ann Otol Rhinol Laryngol. 2006 Aug;115(8):581-6. doi: 10.1177/000348940611500803.
Several studies have explored posttreatment voice outcomes for early glottic cancer with varying results. To further clarify the voice-related quality of life (QOL) of T1 glottic cancer patients treated by external beam radiotherapy (EBRT) compared to endoscopic carbon dioxide laser excision (CLE), we performed a meta-analysis.
We performed a meta-analysis review for the years 1966 to 2005 for the Voice Handicap Index (VHI), laryngeal cancer, voice outcome, voice quality, and quality of life. Studies in which the VHI was assessed at least 3 months after treatment for T1 glottic cancer were identified and analyzed by meta-analysis techniques.
Six studies with 208 patients (6 T1b and 202 T1a) treated with CLE and 91 patients (6 T1b and 85 T1a) treated with EBRT were identified. The posttreatment VHI scores were similar for the EBRT- and CLE-treated patients (p = .1, Wilcoxon rank sum test).
We conclude that CLE and EBRT provide comparable levels of voice handicap for patients with T1 glottic cancer.
多项研究探讨了早期声门癌治疗后的嗓音结果，结果各异。为了进一步阐明与接受外照射放疗（EBRT）的T1声门癌患者相比，接受内镜二氧化碳激光切除术（CLE）的患者的嗓音相关生活质量（QOL），我们进行了一项荟萃分析。
我们对1966年至2005年期间有关嗓音障碍指数（VHI）、喉癌、嗓音结果、嗓音质量和生活质量的研究进行了荟萃分析综述。通过荟萃分析技术，确定并分析了在T1声门癌治疗后至少3个月评估VHI的研究。
确定了6项研究，其中208例患者（6例T1b和202例T1a）接受了CLE治疗，91例患者（6例T1b和85例T1a）接受了EBRT治疗。EBRT组和CLE组治疗后的VHI评分相似（p = 0.1，Wilcoxon秩和检验）。
我们得出结论，对于T1声门癌患者，CLE和EBRT导致的嗓音障碍程度相当。
