感觉功能障碍的一个新维度：精神分裂症中的立体视觉缺陷。
A new dimension of sensory dysfunction: stereopsis deficits in schizophrenia.
作者信息
Schechter Isaac, Butler Pamela D, Jalbrzikowski Maria, Pasternak Roey, Saperstein Alice M, Javitt Daniel C
机构信息
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA.
出版信息
Biol Psychiatry. 2006 Dec 1;60(11):1282-4. doi: 10.1016/j.biopsych.2006.03.064. Epub 2006 Aug 30.
BACKGROUND
Schizophrenia is a neurocognitive disorder with a wide range of cognitive and sensory impairments. Early visual processing has been shown to be especially impaired. This article investigates the integrity of binocular depth perception (stereopsis) in schizophrenia.
METHODS
Seventeen schizophrenia patients and 19 healthy control subjects were compared on the Graded Circles Stereo Test. Results of stereoacuity were compared between patients and control subjects using t test.
RESULTS
Schizophrenia patients demonstrated significantly (p = .006) reduced stereoacuity (mean = 142 arcseconds) versus control subjects (mean = 55 arcseconds). At the normative level for adults, patients performed below chance.
CONCLUSIONS
These findings demonstrate an impairment of binocular depth perception and further confirm deficits of early visual processing in schizophrenia. Findings are discussed in context of magnocellular/dorsal stream processing with implications for visual processing and cognitive deficits.
背景
精神分裂症是一种具有广泛认知和感觉障碍的神经认知障碍。早期视觉处理已被证明尤其受损。本文研究了精神分裂症患者双眼深度感知（立体视觉）的完整性。
方法
对17名精神分裂症患者和19名健康对照者进行了分级圆圈立体视觉测试。使用t检验比较患者和对照者的立体视敏度结果。
结果
与对照者（平均 = 55角秒）相比，精神分裂症患者的立体视敏度显著降低（p = .006）（平均 = 142角秒）。在成人的正常水平上，患者的表现低于随机水平。
结论
这些发现表明双眼深度感知受损，并进一步证实了精神分裂症患者早期视觉处理的缺陷。结合大细胞/背侧流处理对这些发现进行了讨论，其对视觉处理和认知缺陷具有启示意义。
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