Hester R B, Rohrer S D, Liu P I, Coggin J H
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688.
J Natl Cancer Inst. 1990 Jul 18;82(14):1209-14. doi: 10.1093/jnci/82.14.1209.
Two T-cell lines (XR11-4T and XR11-5T), established from radiation-induced, murine lymphoblastic lymphomas, were examined for the expression of class I major histocompatibility complex antigen and tumor induction. These cell lines expressed class I private determinants, H-2.9 and H-2.26, but not the monomorphic determinant defined by monoclonal antibody M1/42. Both cell lines produced tumors in syngeneic and allogeneic hosts. The monomorphic determinant could be demonstrated on both cell lines following growth in allogeneic (BALB/c mice) but not in syngeneic (RFM mice) hosts. The re-expressed determinant present on cells following growth in allogeneic mice was not of host origin. Thus, tumorigenic x irradiation may differentially affect the expression of class I major histocompatibility complex determinants.
对从辐射诱导的小鼠淋巴细胞性淋巴瘤建立的两个T细胞系（XR11 - 4T和XR11 - 5T）进行了I类主要组织相容性复合体抗原表达和肿瘤诱导检测。这些细胞系表达I类私有决定簇H - 2.9和H - 2.26，但不表达由单克隆抗体M1/42定义的单态决定簇。两个细胞系在同基因和异基因宿主中均能产生肿瘤。在异基因（BALB/c小鼠）而非同基因（RFM小鼠）宿主中生长后，两个细胞系均可显示出单态决定簇。在异基因小鼠中生长后的细胞上重新表达的决定簇并非宿主来源。因此，致瘤性X射线照射可能会对I类主要组织相容性复合体决定簇的表达产生不同影响。
