Shinohara Motoo, Chung Yun Jae, Saji Motoyasu, Ringel Matthew D
Divisions of Endocrinology and Oncology, The Ohio State University College of Medicine, 1581 Dodd Drive, Columbus, OH 43210, USA.
Endocrinology. 2007 Mar;148(3):942-7. doi: 10.1210/en.2006-0937. Epub 2006 Aug 31.
AKT (protein kinase B) is a central signaling molecule in the phosphatidyl inositol 3-kinase pathway that is frequently activated in human cancer. AKT activation regulates energy metabolism, apoptosis, proliferation, and migration in many cell systems. In thyroid cancer, AKT activation is involved in tumorigenesis, particularly in both inherited and sporadic forms of follicular thyroid cancer. Phosphatidyl inositol 3-kinase and AKT signaling also appear to play an important role in progression of both papillary and follicular cancers. In this review, the role of AKT in thyroid cancer development and progression are discussed with a focus on areas of current debate in the literature.
AKT（蛋白激酶B）是磷脂酰肌醇3激酶途径中的核心信号分子，在人类癌症中经常被激活。AKT激活在许多细胞系统中调节能量代谢、细胞凋亡、增殖和迁移。在甲状腺癌中，AKT激活参与肿瘤发生，特别是在遗传性和散发性滤泡状甲状腺癌中。磷脂酰肌醇3激酶和AKT信号传导在乳头状癌和滤泡状癌的进展中似乎也起着重要作用。在这篇综述中，将讨论AKT在甲状腺癌发生和进展中的作用，重点关注文献中当前存在争议的领域。
