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Regulation of PDL-1 expression in thyroid carcinoma cells by tumor cell derived cytokines activating STAT3.

作者信息

Klemke Matthias, Veit Nadine, Schmidt-Wolf Ingo, Bundschuh Ralph A, Essler Markus, Kreppel Barbara

机构信息

Department of Nuclear Medicine, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.

Excellence Cluster ImmunoSensation, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.

出版信息

Immunol Res. 2024 Dec 19;73(1):20. doi: 10.1007/s12026-024-09552-y.

DOI:10.1007/s12026-024-09552-y
PMID:39699782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11659334/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/0bd7cae2919a/12026_2024_9552_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/64a70c9dbedd/12026_2024_9552_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/bcfe2fde07d1/12026_2024_9552_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/42a953317b03/12026_2024_9552_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/98f201eaad64/12026_2024_9552_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/72befa34deb6/12026_2024_9552_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/1c61f1b63f53/12026_2024_9552_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/0bd7cae2919a/12026_2024_9552_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/64a70c9dbedd/12026_2024_9552_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/bcfe2fde07d1/12026_2024_9552_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/42a953317b03/12026_2024_9552_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/98f201eaad64/12026_2024_9552_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/72befa34deb6/12026_2024_9552_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/1c61f1b63f53/12026_2024_9552_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/908b/11659334/0bd7cae2919a/12026_2024_9552_Fig7_HTML.jpg

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Regulation of PDL-1 expression in thyroid carcinoma cells by tumor cell derived cytokines activating STAT3.肿瘤细胞衍生的细胞因子激活STAT3对甲状腺癌细胞中PDL-1表达的调控
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本文引用的文献

1
Small molecule drug discovery targeting the JAK-STAT pathway.靶向JAK-STAT通路的小分子药物研发
Pharmacol Res. 2024 Jun;204:107217. doi: 10.1016/j.phrs.2024.107217. Epub 2024 May 21.
2
What is the status of immunotherapy in thyroid neoplasms?免疫疗法在甲状腺肿瘤中的地位如何？
Front Endocrinol (Lausanne). 2022 Aug 5;13:929091. doi: 10.3389/fendo.2022.929091. eCollection 2022.
3
PD-L1 expression and immune cells in anaplastic carcinoma and poorly differentiated carcinoma of the human thyroid gland: A retrospective study.
人甲状腺间变性癌和低分化癌中PD-L1表达与免疫细胞：一项回顾性研究
Oncol Lett. 2021 Jul;22(1):553. doi: 10.3892/ol.2021.12814. Epub 2021 May 24.
4
Immune Landscape of Thyroid Cancers: New Insights.甲状腺癌的免疫全景：新的见解。
Front Endocrinol (Lausanne). 2021 Apr 27;11:637826. doi: 10.3389/fendo.2020.637826. eCollection 2020.
5
Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation.通过 MHC I 类抗原呈递丧失实现癌症免疫逃逸。
Front Immunol. 2021 Mar 9;12:636568. doi: 10.3389/fimmu.2021.636568. eCollection 2021.
6
STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT-MET switch and cancer metastasis.信号转导和转录激活因子3（STAT3）在丝氨酸727（Ser727）和酪氨酸705（Tyr705）位点的磷酸化对上皮-间质转化-间质-上皮转化（EMT-MET）转换及癌症转移具有不同的调节作用。
Oncogene. 2021 Jan;40(4):791-805. doi: 10.1038/s41388-020-01566-8. Epub 2020 Dec 1.
7
Tumor Mutational Burden as a Predictor of Immunotherapy Response: Is More Always Better?肿瘤突变负荷作为免疫治疗反应的预测因子：更多是否总是更好？
Clin Cancer Res. 2021 Mar 1;27(5):1236-1241. doi: 10.1158/1078-0432.CCR-20-3054. Epub 2020 Nov 16.
8
PD-L1 expression increased by IFN-γ via JAK2-STAT1 signaling and predicts a poor survival in colorectal cancer.程序性死亡受体配体1（PD-L1）的表达通过Janus激酶2（JAK2）-信号转导和转录激活因子1（STAT1）信号通路被γ-干扰素（IFN-γ）上调，并预示着结直肠癌患者的不良生存结局。
Oncol Lett. 2020 Aug;20(2):1127-1134. doi: 10.3892/ol.2020.11647. Epub 2020 May 20.
9
THERAPY OF ENDOCRINE DISEASE Immunotherapy of advanced thyroid cancer: from bench to bedside.内分泌疾病治疗 晚期甲状腺癌的免疫治疗：从基础到临床。
Eur J Endocrinol. 2020 Aug;183(2):R41-R55. doi: 10.1530/EJE-20-0283.
10
Lactate induces PD-L1 in HRAS-positive oropharyngeal squamous cell carcinoma.乳酸在HRAS阳性口咽鳞状细胞癌中诱导程序性死亡受体配体1（PD-L1）表达。
Oncotarget. 2020 Apr 28;11(17):1493-1504. doi: 10.18632/oncotarget.27348.