CD4 + 和CD56 + 急性单核细胞白血病
CD4+ and CD56+ acute monoblastic leukemia.
作者信息
Tauchi T, Ohyashiki K, Ohyashiki J H, Kawanishi Y, Kimura Y, Saito M, Nakazawa S, Kawai Y, Toyama K
机构信息
First Department of Internal Medicine, Tokyo Medical College, Japan.
出版信息
Am J Hematol. 1990 Jul;34(3):228-9. doi: 10.1002/ajh.2830340315.
We report here a patient with acute monoblastic leukemia whose leukemia cells had CD4 (T4) and CD56 (NKH-1) antigens, in addition to CD36 (OKM5) antigen. The leukemia cells did not have NK or ADCC activities. They showed no rearrangements of immunoglobulin heavy (IgH) chain and T cell receptor (TCR)-beta chain genes, indicating that the leukemia cells were nonlymphoid. The presence of this case suggests that leukemia cells could be originated from monocytes with NK-associated antigen without IgH or TCR rearrangements.
我们在此报告一名急性单核细胞白血病患者，其白血病细胞除了有CD36（OKM5）抗原外，还具有CD4（T4）和CD56（NKH-1）抗原。白血病细胞没有自然杀伤（NK）或抗体依赖的细胞介导的细胞毒性（ADCC）活性。它们未显示免疫球蛋白重链（IgH）和T细胞受体（TCR）-β链基因重排，表明白血病细胞是非淋巴细胞性的。该病例的存在提示白血病细胞可能起源于带有NK相关抗原且无IgH或TCR重排的单核细胞。
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