Leu Chien-Hsing, Li Chia-Ying, Yao Xinsheng, Wu Tian-Shung
Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, ROC.
Chem Pharm Bull (Tokyo). 2006 Sep;54(9):1308-11. doi: 10.1248/cpb.54.1308.
Three new coumarins, phellodenols F-H (1-3) and a new glutaric acid derivative, phellodendric acid-A (4) were isolated from the leaves of Phellodendron amurense together with twenty-nine known compounds. Extensive 1D and 2D NMR experiments and other spectroscopic studies were employed to determine the structures of 1-4. The isolated compounds were screened for their antioxidant activity through DPPH (alpha,alpha-diphenyl-beta-picrylhydrazyl) radical scavenging assay. Compounds quercetin, quercetin-3-O-beta-D-glucoside, quercetin-3-O-beta-D-galactoside and kaempferol-3-O-beta-D-glucoside demonstrated significant radical scavenging activity comparable to vitamin E.
从黄檗叶中分离出三种新香豆素，黄柏醇F - H（1 - 3）和一种新的戊二酸衍生物，黄柏酸 - A（4），以及29种已知化合物。采用广泛的一维和二维核磁共振实验及其他光谱研究来确定1 - 4的结构。通过DPPH（α，α - 二苯基 - β - 苦基肼）自由基清除试验对分离出的化合物进行抗氧化活性筛选。化合物槲皮素、槲皮素 - 3 - O - β - D - 葡萄糖苷、槲皮素 - 3 - O - β - D - 半乳糖苷和山奈酚 - 3 - O - β - D - 葡萄糖苷表现出与维生素E相当的显著自由基清除活性。
