Rusthoven J J, Daya D
Hamilton Regional Cancer Center, Ontario, Canada.
Arch Pathol Lab Med. 1990 Jul;114(7):728-31.
We report a case of small-cell carcinoma of the vagina in a women whose entire uterus, cervix, both fallopian tubes, and both ovaries had been removed 22 years previously. She presented with diffuse submucosal disease of the distal vagina with a possible soft-tissue component extending beyond the end of the vaginal vault. Extensive microscopic and immunohistochemical assessment established the diagnosis; treatment was initiated with chemotherapy, followed by local radiotherapy. To our knowledge, this is the first fully characterized case of its kind. We discuss the aggressive local behavior and the characteristics of gynecologic small-cell tumors in general.
我们报告了一例阴道小细胞癌病例，患者22年前已切除整个子宫、宫颈、双侧输卵管和双侧卵巢。她表现为阴道远端弥漫性黏膜下病变，可能有软组织成分延伸至阴道穹窿末端之外。广泛的显微镜检查和免疫组化评估确立了诊断；治疗首先采用化疗，随后进行局部放疗。据我们所知，这是首例此类特征完全明确的病例。我们讨论了其侵袭性的局部行为以及妇科小细胞肿瘤的一般特征。
