Prasad C J, Ray J A, Kessler S
Department of Pathology, Oregon Health Sciences University, Portland 97201.
Cancer. 1992 Nov 15;70(10):2484-7. doi: 10.1002/1097-0142(19921115)70:10<2484::aid-cncr2820701015>3.0.co;2-o.
Primary small cell carcinoma of the vagina is rare, with only nine cases published to date. The authors report what they believe to be the first case of primary small cell carcinoma of the vagina arising in a setting of atypical adenosis.
The tumor was studied by light and electron microscopy and immunohistochemistry.
Intracytoplasmic electron-dense neurosecretory type granules were seen, and immunohistochemical demonstration of chromogranin A was documented.
These features were found to be similar to small cell carcinomas arising elsewhere in the female genital tract (i.e., cervix, endometrium, ovary, and vulva).
原发性阴道小细胞癌罕见，迄今为止仅有9例报道。作者报告了他们认为首例发生于非典型腺病背景下的原发性阴道小细胞癌病例。
通过光镜、电镜及免疫组化对肿瘤进行研究。
可见胞质内电子致密的神经分泌型颗粒，并记录到嗜铬粒蛋白A的免疫组化显示。
发现这些特征与女性生殖道其他部位（即宫颈、子宫内膜、卵巢和外阴）发生的小细胞癌相似。
