Sommers S C, Melamed J
Lenox Hill Hospital, New York City.
Am J Hypertens. 1990 Jul;3(7):583-7. doi: 10.1093/ajh/3.7.583.
Microscopic analysis of over 2,000 renal biopsies taken at surgical sympathectomy operations has been correlated with blood pressures in essential hypertension. Statistically significant relationships exist between the average diastolic pressure and the degree of afferent renal arteriolar thickening and narrowing. Postoperative prognosis was favorable with all but the most severe and diffuse arteriolar sclerosis, and vascular fibrinoid necrosis did not affect survival. Juxtaglomerular cell hyperplasia and inferred renin hypersecretion were significantly involved in the kidney biopsies of essential hypertension. Diabetic juxtaglomerular cell atrophy and sclerosis reduced this component of hypertension. After age 80, kidneys at autopsy showed no evident relation between arteriolar lesions and hypertension.
对手术交感神经切除术时获取的2000多份肾活检标本进行显微镜分析，并将其与原发性高血压患者的血压进行了关联研究。平均舒张压与肾入球小动脉增厚和狭窄程度之间存在统计学上的显著关系。除了最严重和弥漫性的小动脉硬化外，术后预后良好，血管纤维蛋白样坏死不影响生存率。原发性高血压患者的肾活检标本中，肾小球旁细胞增生及由此推断的肾素分泌过多显著相关。糖尿病患者的肾小球旁细胞萎缩和硬化减轻了高血压的这一组成部分。80岁以后，尸检肾脏显示小动脉病变与高血压之间无明显关系。
