Poduslo S E, Pak C H, Miller K
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Neurosci Lett. 1990 May 18;113(1):84-8. doi: 10.1016/0304-3940(90)90499-y.
Steroid hormones are important for the normal development of brain. The addition of hydrocortisone to oligodendroglia in culture increases the level of mRNA for proteolipid protein, increases the synthesis of cerebrosides, and provides an induction of activities for the ketone body metabolizing enzymes. While proteolipid protein and cerebrosides are major components of myelin membranes, ketone bodies serve as precursors for lipid synthesis during development. Thus, hydrocortisone is important during the differentiation of oligodendroglia and during initial myelin production.
类固醇激素对大脑的正常发育至关重要。在培养的少突胶质细胞中添加氢化可的松可提高蛋白脂蛋白的mRNA水平，增加脑苷脂的合成，并诱导酮体代谢酶的活性。虽然蛋白脂蛋白和脑苷脂是髓鞘膜的主要成分，但酮体在发育过程中作为脂质合成的前体。因此，氢化可的松在少突胶质细胞分化和初始髓鞘形成过程中很重要。
