慢性鼻窦炎患者骨重塑的CT分析与组织病理学研究
CT analysis and histopathology of bone remodeling in patients with chronic rhinosinusitis.
作者信息
Cho Seok Hyun, Min Hyun Jung, Han Hong Xiu, Paik Seung Sam, Kim Kyung Rae
机构信息
Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Hanyang University, Haeng-dang-dong 17, Sungdong-gu, Seoul 133-792, Korea.
出版信息
Otolaryngol Head Neck Surg. 2006 Sep;135(3):404-8. doi: 10.1016/j.otohns.2006.04.005.
OBJECTIVE
To evaluate the findings of computed tomography (CT) and histopathology of the bulla ethmoidalis as objective markers of bone remodeling in chronic rhinosinusitis (CRS).
METHODS
Preoperative ostiomeatal unit (OMU) scans and histopathologic findings of the bulla ethmoidalis were performed on 23 patients (39 sides) undergoing endoscopic sinus surgery for CRS. Lund-Mackay scores and Hounsfield units (HU) of the bulla were checked in coronal CT scans. The pathologist graded the severities of the mucosal and bony changes in histopathology. Statistical analysis was performed using Mann-Whitney U test and Spearman correlation coefficient (r).
RESULTS
The HU values of the bulla were significantly increased with higher Lund-Mackay scores in OMU CT (r = 0.405, P = 0.01). The bony grades in histopathology were significantly increased with higher mucosal grades (r = 0.821, P = 0.0001). These findings in CT scans and histopathology were well correlated with each other (r > 0.3, P < 0.05).
CONCLUSION
HU may be a useful objective marker of bone remodeling in chronic rhinosinusitis.
目的
评估筛泡的计算机断层扫描（CT）和组织病理学检查结果，作为慢性鼻-鼻窦炎（CRS）骨重塑的客观标志物。
方法
对23例（39侧）因CRS接受鼻内镜鼻窦手术的患者进行术前窦口鼻道复合体（OMU）扫描及筛泡的组织病理学检查。在冠状位CT扫描中检查筛泡的Lund-Mackay评分和Hounsfield单位（HU）。病理学家对组织病理学中黏膜和骨质变化的严重程度进行分级。采用Mann-Whitney U检验和Spearman相关系数（r）进行统计学分析。
结果
在OMU CT中，筛泡的HU值随Lund-Mackay评分升高而显著增加（r = 0.405，P = 0.01）。组织病理学中的骨质分级随黏膜分级升高而显著增加（r = 0.821，P = 0.0001）。CT扫描和组织病理学的这些结果相互之间具有良好的相关性（r > 0.3，P < 0.05）。
结论
HU可能是慢性鼻-鼻窦炎骨重塑的有用客观标志物。
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