第3章：患有和未患有宫颈肿瘤疾病的女性的人乳头瘤病毒（HPV）型别分布

Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases.

作者信息

Clifford Gary, Franceschi Silvia, Diaz Mireia, Muñoz Nubia, Villa Luisa Lina

机构信息

International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon cedex 08, France.

出版信息

Vaccine. 2006 Aug 31;24 Suppl 3:S3/26-34. doi: 10.1016/j.vaccine.2006.05.026. Epub 2006 Jun 2.

DOI:10.1016/j.vaccine.2006.05.026

PMID:16950015

Abstract

Geographical widespread data on human papillomavirus (HPV) type-distribution are essential for estimating the impact of HPV-16/18 vaccines on cervical cancer and cervical screening programmes. Epidemiological studies employing a variety of HPV typing protocols have been collated in meta-analyses. HPV-16/18 is estimated to account for 70% of all cervical cancers worldwide, although the estimated HPV-16/18 fraction is slightly higher in more developed (72-77%) than in less developed (65-72%) regions. About 41-67% of high-grade squamous intraepithelial lesion (HSIL), 16-32% of low-grade squamous intraepithelial lesion (LSIL) and 6-27% of atypical squamous cells of undetermined significance (ASCUS) are also estimated to be HPV-16/18-positive, thus highlighting the increasing relative frequency of HPV-16/18 with increasing lesion severity. After HPV-16/18, the six most common HPV types are the same in all world regions, namely 31, 33, 35, 45, 52 and 58; these account for an additional 20% of cervical cancers worldwide.

摘要

关于人乳头瘤病毒（HPV）型别分布的广泛地理数据对于评估HPV - 16/18疫苗对宫颈癌及宫颈筛查项目的影响至关重要。采用多种HPV分型方案的流行病学研究已在荟萃分析中进行了整理。据估计，HPV - 16/18在全球所有宫颈癌中占70%，不过在较发达地区（72 - 77%），HPV - 16/18的估计占比略高于欠发达地区（65 - 72%）。据估计，约41 - 67%的高级别鳞状上皮内病变（HSIL）、16 - 32%的低级别鳞状上皮内病变（LSIL）以及6 - 27%的意义未明的非典型鳞状细胞（ASCUS）也为HPV - 16/18阳性，这凸显了随着病变严重程度增加，HPV - 16/18的相对频率也在上升。除HPV - 16/18外，全球所有地区最常见的六种HPV型别相同，即31、33、35、45、52和58；这些型别在全球宫颈癌中额外占20%。